A BS "HA C T Pspects of the lubrication requirements f o r an automatic capsule filling machine, instrumented to monitor compression and ejection forces, were studied under various filling conditions. Three common capsule fillers (compressible starch, microcrystalline cellulose, and anhydrous lactose) were filled into No. 1 gelatin capsules. Two main sets of runs were made. The first set was designed to study the influence of powder bed height, piston height and compression force on the ejection forces generated during the filling process. The second set was aimed at comparing lubricant type and levels. It was shown that the ejection force is increased by increasing the powder bed height, piston height and compression force. Compressible starch and microcrystalline cellulose required relatively low levels345 Copyright 0 1978 by Marcel Dekker, Inc. All Rights Reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dev Ind Pharm Downloaded from informahealthcare.com by Fudan University on 05/15/15 For personal use only. SMALL AND AUGSBURGER of magnesium stearate as compared to anhydrous lactose. The performance o f stearic acid and especially magnesium lauryl sulfate compared favorably with magnesium stearate in compressible starch. Drug Dev Ind Pharm Downloaded from informahealthcare.com by Fudan University on 05/15/15 For personal use only.

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