Effect of disintegrants on drug dissolution from capsules filled on a dosator-type automatic capsule-filling machine

Botzolakis, John E.; Small, L.E.; Augsburger, Larry L.

doi:10.1016/0378-5173(82)90105-3

Cited by 20 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also PVCL collapses when the temperature exceeds 32 1C [23] and, therefore, the thermosensitive PVCL has, presumably, similar characteristics as PNIPAM. PVCL is a chemical analogue of polyvinylpyrrolidone (PVP), a well-known and widely used pharmaceutical excipient [24][25][26][27]. However, some evidences of PVP dose-and time-dependent toxicity have been found recently [28].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam)

et al. 2005

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam)

et al. 2005

View full text Add to dashboard Cite

“…The crystal of starch disappeared after water immersion that consistent with the results of particle size (Figure 2b and c). The dissolution and disintegration of the microcapsule were conducive to the procyanidins release (Botzolakis et al, 1982).…”

Section: Sem Analysis Of Mps and Mpswmentioning

confidence: 99%

Microencapsulated procyanidins by extruding starch improved physicochemical properties, inhibited the protein and lipid oxidant of chicken sausages

Song

Jiang

et al. 2022

Journal of Food Science

View full text Add to dashboard Cite

Microencapsulated procyanidins by extruding starch (MPS) were used in meat and meat products as an antioxidant for their simple production process and high stability. This study investigated the controlled released properties of MPS and their effect on antioxidant capacity, physicochemical properties, and sensory qualities of chicken sausages during 4 • C storage within 28 days. Antioxidant capacity, particle size analysis, and simulated digestion in vitro demonstrated that microencapsulation by extruding starch delayed the procyanidins release. The reduced crystal structure of MPS was determined by the morphology observation (SEM) and the decrease of the typical diffraction peak at 2θ of 20.9 • (XRD). The MPS-added sausage had a higher (p < 0.05) ABTS and DPPH radical scavenging ratio (97.6% and 67.3%) and sulfhydryl contents (114.69 nmol/g protein) than other groups. Moreover, lower (p < 0.05) thiobarbituric acid reactive substances (TBARS) (0.67 mg MDA/kg sausage) and carbonyl values (3.24 nmol/mg protein) were detected in MPS-added sausages than others at the end of storage. The MPS addition increased redness (a* value) and decreased the lightness (L* value). The sensory analysis suggested that the sausage with the increased redness was favorable. These results denominated that MPS was an alternative antioxidant in chicken sausages.Practical Application: In this study, microencapsulated procyanidins were prepared by extrusion technology, and the effect on the quality of chicken sausages was investigated, which provides an alternative natural antioxidant for meat and meat products.

show abstract

“…The dissolution fluid is 900 mL of 0.1 N HCl maintained at 37±0.5 ºC at an agitational speed of 75 rpm (Riikka, et al, 2010;Botzolakis, Small, Augsburger, 1982). Samples equal to 2 mL were withdrawn at an interval time of 1min and up to 7 min, and the concentration was read on spectrophotometer at 281 nm.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics

Jayaramu

Boregowda²,

Varma³

et al. 2014

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Formulation of FDT (fast dispersing tablets) of nebivolol was optimized and evaluated using simplex lattice design (SLD). The influence of type and concentration of three disintegrants viz., Ac-Di-Sol, Primojel and Polyplasdone XL on hardness, friability and disintegration time of tablet was studied.Response surface plot and the polynomial equations were used to evaluate influence of polymer on the tablet properties. Results were statistically analyzed using ANOVA, and a p < 0.05 was considered statistically significant. Results reveal that fibrous integrity and optimal degree of substitution in Primojel and Ac-Di-Sol are mainly responsible for the hardness of the tablet. Use of Polyplasdone in higher percentage in tablet formulation may result in high friability. Increase in concentration of Ac-Di-Sol increases the disintegration time but increased concentration of Primojel in the tablet formulation decreases the disintegration time. This is also evident from model terms for disintegration time with a high 'F' value of 14.69 and 'p' value of 0.0031 (<0.05). The reason could be that Primojel has higher swelling properties and an optimum hydration capacity, which favors fast disintegration of a tablet. In conclusion, careful selection of disintegrant for FDT could improve their properties. Use of Simplex Lattice Design for formulation development could simplify the formulation process and reduce the production cost.Uniterms: Nebivolol/fast dispersing tablets. Simplex lattice design. Tablets/fast dispersing/swelling capacity. Tablets/fast dispersing/hydration capacity. Tablets/fast dispersing/disintegration time.Otimizou-se e avaliou-se formulação de comprimidos de dispersão rápida (CDR) de nebivolol, usando planejamento de grade simplex (PGS). Estudou-se a influência do tipo e da concentração de três desintegrantes viz, Ac-Di-Sol, Primojel e Poliplasdona XL, na dureza, friabilidade e tempo de desintegração do comprimido. O gráfico de superfície de resposta e as equações polinomiais foram utilizados para avaliar a influência do polímero nas propriedades do comprimido. Os resultados foram analisados estatisticamente por ANOVA, considerando-se p < 0,05 como estatisticamente significativo. Os resultados revelam que a integridade das fibras e o grau de substituição ótimo no Primojel e AcDi-Sol são os principais responsáveis pela dureza do comprimido. O uso de Poliplasdona em maior porcentagem na formulação pode produzir friabilidade elevada. O aumento de Ac-Di-Sol aumenta o tempo de desintegração, mas o aumento da concentração de Primojel na formulação diminui o tempo de desintegração. Isto é, também, evidente no modelo de tempo de desintegração com alto valor de "F" de 14,69 e "p" de 0,0031 (< 0,05). A razão poderia ser que o Primojel tem maiores propriedades de intumescimento e ótima capacidade de hidratação, favorecendo a desintegração rápida do comprimido. Em conclusão, a cuidadosa seleção de um desintegrante para CDR poderia aprimorar suas propriedades. O uso do PGS para o desenvolvimento da formulação poderia si...

show abstract

Effect of disintegrants on drug dissolution from capsules filled on a dosator-type automatic capsule-filling machine

Cited by 20 publications

References 10 publications

Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam)

Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam)

Microencapsulated procyanidins by extruding starch improved physicochemical properties, inhibited the protein and lipid oxidant of chicken sausages

Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics

Contact Info

Product

Resources

About