ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis and Some Reactions of 2-Acetylimidazo [4,5-b]pyridine. Antituberculotic Activity of the Obtained Compounds.-A series of new derivatives of the imidazo[4,5-b]pyridine system is synthesized based on reactions of the title compound (IV) with aromatic amines [→(VI), (VII)], hydrazides [→(IX)], aromatic aldehydes [→(XI)], and thiourea [→(XIII)]. Most of the obtained compounds are screened for their in vitro antituberculotic activity. -(BUKOWSKI, L.; JANOWIEC, M.; ZWOLSKA-KWIEK, Z.; ANDRZEJCZYK, Z.; Pharmazie 54 (1999) 9, 651-654; Dep. Org. Chem., Med. Univ. Gdansk, PL-80-416 Gdansk, Pol.; EN)
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
New derivatives of imidazo[4,5-b]pyridine and 9H-dipyrido-[1,2-a:3',2'-d]imidazole were synthesized. Antibacterial activity against Mycobacterium tuberculosis of selected compounds was determined. These data were combined with the corresponding bioactivity data previously generated for two other series of imidazo[4,5-b]pyridines. Analysis of Quantitative Structure-Activity Relationships [QSAR] was carried out using nonempirical structural descriptors. Hydrophobicity of the agents studied was found decisive for their activity. A QSAR equation was derived allowing rational design of active derivatives.
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