ChemInform Abstract: Some Reactions of 2‐Cyanomethylimidazo[4,5‐b]pyridine with Isothiocyanates. Antituberculotic Activity of the Obtained Compounds.

Bukowski, L.; Janowiec, M; Zwolska, Zofia; Andrzejczyk, Z

doi:10.1002/chin.199844146

Cited by 15 publications

(15 citation statements)

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“…These compounds display a broad spectrum of biological activities, such as antimycobacterial [7][8][9][10], antifungal [11][12][13], antiviral [14][15][16][17][18], anticancer [13], and anticonvulsant [19] activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of new 4-thiazolidinone derivatives

Güzel

Salman

2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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A series of new 2-aryl-4-thiazolidinones (3 and 4) was synthesized from 2-hydroxy-2,2-diphenyl-N'-[(substituted phenyl)methylene]acetohydrazides (2) and mercaptoacetic acid or 2-mercaptopropionic acid. The antimycobacterial activity of these compounds was determined and several leads with 95-99% inhibition at 6.25 µg/mL test concentration were identified. In addition, antitumor activities were measured against several tumor cell lines, and significant growth inhibition was observed for compound 4p. Taken together, 2-aryl-4-thiazolidinones were shown to be promising scaffolds for both antimycobacterial and tumor-targeting compounds.

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Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of new 4-thiazolidinone derivatives

Güzel

Salman

2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Thiazolidine-4-one scaffold has gained prominence in recent years as it possesses antibacterial [106,107], antifungal [108,109], anticonvulsant [110,111], antituberculosis [112,113] and anticancer activities. The antiviral activity of thiazolidine-4-one scaffold was emphasized in several studies.…”

Section: Thiazolidine-4-one Derivativesmentioning

confidence: 99%

A Review on Anti-HCV Agents Targeting Active Site and Allosteric Sites of Non-Structural Protein 5b [Ns5b]

Polamreddy

Vishwakarma

Gundla

2016

Int J Pharm Pharm Sci

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Hepatitis C, a chronic disease affecting the global population significantly is caused majorly by Hepatitis C virus [HCV]. Among the several druggable targets explored for Hepatitis C, the viral protein, non-structural protein 5B [NS5B] is the target of choice for researchers as it is the key enzyme in the HCV replication and its active site is conserved among all genotypes. In the recent years the landscape of Hepatitis C therapies, have evolved from Peg-Interferon [PEG-INF]/Ribavirin, to directly acting anti-virus along with PEG-INF and finally, INF free regimens with greater than 90% sustained virological response [SVR]. The launch of Sofosbuvir, a nucleotide inhibitor of NS5B marks the major paradigm in hepatitis C research. Sofosbuvir exhibits, pan-genotypic activity, low barrier to resistance, highly effective and safe. However, the high prices of these medications limit their universal access. This review will focus on progress towards the discovery and development of NS5B inhibitors targeting allosteric sites and active site, covering the chemical class and structure-activity relationships.

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“…Condensation of carbohydrazides 1 with 2‐acetyl‐imidazo[4,5‐ b ]pyridine 10 in absolute ethanol containing a catalytic amount of piperidine afforded the corresponding hydrazones 11 [31]. …”

Section: Reactions Of Carbohydrazidesmentioning

confidence: 99%