A369 on HRQoL of the general population is still lacking. The aim of our study was to fill this GAP. Methods: A dataset with HRQoL data of a representative sample of the general population of most populated Italian region was matched with the dataset from a multicenter study conducted in the same region and time period to generate and validate a set of health care outcomes indicators for the major LDs (hepatitis B (HBV), hepatitis C (HCV), compensated cirrhosis (CC), decompensated cirrhosis (DC), hepatocellular carcinoma (HCC), autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), NAFLD/ NASH and patients listed for liver transplant (LTL)). Within both datasets, HRQoL data were collected using the EQ-5D-3L. Multivariate logistic and Tobit regressions were then performed adjusting for possible confounders (age, sex, education and working status). Results: A total of 6,800 "healthy subjects" and 3,105 subjects with LDs were included in the analyses. Multivariate logistic analyses showed that DC, HCC, and LTL had significantly (p< 0.05) higher risk to have problems in mobility, self-care, and usual activities compared to "healthy subjects". AIH had significantly higher risk to have problems in self-care; while HCV, CC, DC, and NAFLD/NASH in Anxiety/depression. Similar results were obtained with the Tobit model performed using VAS and Utility-index. DC, HCC, AIH and LTL reported the highest decrease in VAS and Utility score. ConClusions: HRQoL decreased in advanced LDs (DC, HCC, LTL) and AIH. This study provides an actual true estimate of the impact of major LDs on the patients' HRQoL compare to the general population, and therefore is a key tool for decision-making in care delivery for liver diseases.

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We present an interim analysis of the retrospective data from Spain. MethOds: This is an observational, retrospective-prospective (±6-months(m)) study in patients diagnosed in the last five years of IBS-C (Rome-III criteria) of moderate-to-severe degree (IBS-Symptom Severity Score(IBS-SSS)≥ 175). Quality-of-life(QoL) was assessed with the EuroQoL-5D(EQ-5D) and IBS-QoL. Results: We included 46 patients (62% severe, mean(±SD) 44.6±12.2 years, 83% women, time since diagnosis 2.8±3.6 years). According to IBS-SSS, 94% had abdominal pain in the last month (62% of time) and 85% abdominal distention. Other prevalent symptoms were: constipation (96%), abdominal discomfort (72%) and bloating (59%). Mean IBS-QoL was 46±23, on a scale 0-100 (worst QoL), and the most affected domains were "food avoidance" (mean:64) and "health worry" (60). Mean EQ-5D was 51±20, on a scale 0-100 (best QoL), and 93% and 70% of patients, respectively, reported problems in pain/discomfort and anxiety/ depression. In the previous 6m, 83% of patients consulted a primary care physician, and 89% a specialist (mostly a gastroenterologist)(mean(95%CI):2.8(1.4-4.3) and 2.0(0.9-3.1) visits, respectively). 20% of patients required emergency department visits or hospitalization (mean stay:1.3(0.6-1.9) days). 76% of patients underwent a diagnostic test (mean:2.1(1.3-2.9) tests). 89% of patients took medication (63% prescription drugs and 54% OTC medications), 26% received complementary therapies. The mean direct costs per patient for the National Health System(NHS) were € 1,025/6m(549-1627) and the mean costs for the patient were € 200/6m. 17% of patients had sick leave(mean:3.5 leaves; mean duration:58 days) and 46% had productivity losses(mean:49 hours). Mean indirect costs were € 991/6m. Total costs amounted to € 2216/6m. cOnclusiOns: Moderate-to-severe IBS-C has a great impact on health care resource utilization and productivity of patients, and the results suggest significant costs to the NHS and society. QoL can be severely affected. PGI45 hEalth-rElatEd QualIty of lIfE (hrQl) In chronIc hEPatItIS c (ch-c) PatIEntS trEatEd wIth SofoSBuvIr contaInInG IntErfEron-frEE rEGImEnS

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