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Abstract. C20H27FO , M r = 302.41, monoclinic, P2~/c, a=6.105(5), b=21.673(22), c=13.925(7)/~, fl = 96.66 (5) ° , V= 1830 (2),~3, Z=4, Dx= 1.10, D m = 1.09 (1) gcm -3, ~(Mo Ka) = 0.71073/~, /1 = 0.68 cm -~, F(000) = 656, T= 298 K, R = 0.062, wR =0.046 for 1797 unique observed reflections. The principal distortions in the polyene portion of the molecule can be seen in the angles opposite the methyl groups (119.9 and 121.7 °, a steric effect) and that opposite fluorine (131.9 ° , an inductive effect). The hexene ring is in the half-chair form, and its double bond is not in conjugation with the all-trans chain.

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ChemInform Abstract The absolute stereochemistry is determined by an X-ray analysis of lankalapuol A acetate (Ib) (space group P21; Z=4).

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875progress in our laboratory to determine the utility of this X-ray crystallographic approach to the design of potent and specific PAF antagonists and an improved drug-receptor site binding model.