Objectives: This study was to discuss the research trend of dementia treatment using cannabis for the purpose of providing the basis of cannabis use for medical purposes in the future.Methods: This study searched publications, which were registered to databases or published by Aug 22, 2019, and targeted the full-text or abstracts of these publications. We selected the final nine studies met all selection criteria.Results: These results implied that the CBD components of cannabis might be useful to treat and prevent AD because CBD components could suppress the main causal factors of AD. Moreover, it was suggested that using CBD and THC together could be more useful than using CBD or THC alone.
Conclusion:We hope that there will be a solid foundation to use cannabis for medical use by continuously evaluating the possibility of using cannabis for clinical purposes as a dementia treatment substance and cannabis can be used as a positive tool.
1.IntroductionThe interest in senile disease is rising gradually because aging society has become a more common phenomenon. Types of dementia include AD, vascular dementia, paralytic dementia, Lewy body dementia, carbon monoxide induced dementia, and trauma dementia [1,2]. The onset of AD has continued to increase since 1995, while the prevalence of vascular dementia is gradually decreasing. Therefore, AD draws attention from researchers [3]. AD is a disease that is caused by the gradual degeneration and death of cerebral cortical cells. The main symptoms are memory loss, cognitive decline and behavioral disorders [4]. Histopathologically, overall encephalatrophy, senile plaques, and neurofibromatosis (NFT) are the common characteristics of AD [5]. Acquired cognitive deficits caused by AD have a significant impact on the social life and activity of the patients [6]. Moreover, active treatment of memory disorders greatly affects the prognosis of AD patients [3]. Consequently, many researchers acknowledge the need for a therapeutic drug to restore the memory and cognitive damages of AD patients, and various studies have been conducted. There are three Cannabis species: C. sativa, C. indica,
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