Krü ppel-like factor 6 (KLF6) is a member of a growing family of transcription factors that share a common 3 C 2 H 2 zinc finger DNA binding domain and have broad activity in regulating proliferation and development. We have previously established that Klf6 is expressed in neuronal tissue, hindgut, heart, lung, kidney, and limb buds during midgestation. To explore the potential role of Klf6 in mouse development, we analyzed Klf6 ؊/؊ mice and found that the homozygous mutation is embryonic lethal by embryonic day (E) 12.5 and associated with markedly re-

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