Yolk sac tumor (YST), which most frequently arises in the gonads as a type of germ cell tumor, is rare in children but is highly malignant. It has been suggested that alpha-fetoprotein (AFP) can be applied as a feasible tumor marker because its level was elevated in >90% of YST. The treatment generally involves debulking surgery of tumors followed by systemic chemotherapy. Metastasis process of YST in children is different from that in adults and thus the treatment option is required. In this study, we described a rare case of YST in terms of the clinical manifestation, imaging, and histopathology findings, diagnosis and treatment in an 8-year-old girl. Furthermore, it is important to investigate more thoroughly a patient with history of intermittent abdominal pain and fever with previously multiple accesses, because these might be the critical signs for YST that should be alarmed for early treatment. Although YST is rare in children, pediatric physicians should be aware of this and prompt treatment should be addressed.
Ginkgo biloba is a large, deciduous tree that matures to 100' tall and is considered to be a living fossil. It is the only surviving member of a group of ancient plants believed to have inhabited the earth up to 150 million years ago. In traditional Chinese medicine, G. biloba preparations have been used for centuries for the management of disorders such as anxiety, allergy, dementia, eye problems, peripheral artery disease, tinnitus, liver fibrosis, hepatocellular carcinoma, and cardiovascular health. Centuries of experience has also shown it to be safe and effective to be used as herbal medicine. This short review, dedicated to the memory of Prof. Keith A. Wesnes, summarizes in vitro and in vivo human studies documenting therapeutic effects of G. biloba preparations for human health.
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