Mültecilik olgusu, ülkenin iç, sosyal ve eğitim politikasında değişikliği gerekli kılar. Bu çalışmada, Eskişehir'e göç eden lise dönemindeki öğrencilerin buradaki eğitim süreçlerine ilişkin algılarının, yaşadıkları sorunların, eğitim ve din eğitiminden beklentilerinin tespit edilmesi amaçlanmıştır. Karma yöntemin benimsendiği bu çalışmada Eskişehir'de devlet okullarında eğitim alan 83 sığınmacı öğrenci ile bu öğrencilere eğitim veren 42 öğretmenin konuya ilişkin görüşleri, yarı yapılandırılmış görüşme formları ve anketler aracılığıyla toplanmıştır. Elde edilen veriler kategorik içerik analizi ile temalandırılmış, ilgili başlıklar altında öğrenci ve öğretmen görüşleri birlikte sunulmuştur. Çalışmada öğrencilerin dil bilmemelerinin, sosyal hayatlarında ve okul süreçlerinde en temel uyum problemi olduğu, bunun farklı sorunlara neden olabildiği tespit edilmiştir. Öğrencilerin din eğitimine ilişkin algılarının okul türüne göre farklılık gösterdiği görülmüştür.
The sirtuin (SIRT) gene family is reported to regulate critical intracellular processes from aging to cellular metabolism and repair. SIRT3 knockout (SIRT3 -/-) mice develop receptor positive mammary tumors starting at 13 months and SIRT3 expression is decreased in human breast cancer samples as well as several other diseases. It is established that carcinogenesis results from the accumulation of multiple aberrant genetic events including the activation of oncogenes and inactivation of tumor-suppressor genes. To determine the potential early genomic events that may play a role in the tumor-permissive phenotype observed in SIRT3 -/cells, we compared gene expression profile in SIRT3 -/and wild-type (SIRT3 +/+ ) mouse livers. Differences between the expression profiles of genes important in the p53 and apoptosis pathway and signal transduction pathways, as well as genes involved with insulin and cholesterol metabolism, were determined. These results demonstrate that the expression of several oncogenes including Cdkn1, Myc, and Nos2 are increased. In contrast, several genes shown to be downregulated in human breast cancer including Btg2, Egr-1, Fos, Jun, Gadd4, and Wnt1 had decreased expression. The current work demonstrates that the loss of function of SIRT3 results in a cellular environment permissive for carcinogenesis and is characterized by altered metabolism.
This paper presents a novel ultrasensitive and rapid impedimetric biosensor with new immobilisation materials for parathyroid hormone (PTH) with the aim to determine the PTH level in serum for the diagnosis and monitoring of parathyroid diseases such as hyperparathyroidism, adenoma, and thyroid cancer. The interaction between PTH and the biosensor was investigated with an electrochemical method. The biosensor was based on the gold electrode modified by mercaptohexanol (6-MHL). Anti-parathyroid hormone (anti-PTH) was covalently immobilised onto a self-assembled monolayer (SAM) by using epiclorhidrina (EPI) with ethanolamine (EA). The EPI-EA interaction represents the first use of these for the construction of biosensors in published reports. The immobilisation of the anti-PTH was monitored by electrochemical impedance spectroscopy, cyclic voltammetry and scanning electron microscopy (SEM) techniques. After the optimisation studies of immobilisation materials such as 6-MHL, EPI, EA and glutaraldehyde, linearity, repeatability and sensitivity of biosensor were evaluated as the performance of biosensor. PTH was detected within a linear range of 0.1-0.6 pg/ml, and the detection limit was 0.1 fg/ml. The specificity of the biosensor was also investigated. Finally, the described biosensor was used to detect the PTH levels in artificial serum samples.
QT interval is one of the important reasons of severe and life threatening ventricular arrhythmias in humans and animals. Many formulas have been developed for correcting the QT interval however the best formula did not define yet by the researchers. For this reason, forty-nine clinically healthy Kangal dogs without cardiac problems other than sinus arrhythmia were included to the study. In this study corrected QT interval was determined by Bazet (QTcB = QT/√RR), Fridericia (QTcF = QT/ 3 √RR), Famingham (QT+0.154(1-RR)), Van der Water (QTcVdW = QT-0.087((60/HR)-1)), Hodges (QT+0.00175(HR-60)), Matsunaga (QTcM = log600 QT/logRR) formulas. As a result, Bazett's formula showed the best consistency because the slope curve of the regression line was closest to zero (-0.00743) in our study.
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