This study indicated that (177)Lu-EDTMP was an effective and safe treatment for palliation of metastatic bone pain in patients with prostate or breast cancer. A dose of 1295 MBq (35 mCi) was sufficient for bone pain palliation therapy, and doses as high as 2590 MBq (70 mCi) were well tolerated.

To evaluate the association between psoriasis and risk of diabetes, pertinent studies were identified by searching electronic databases and by reviewing the reference lists of retrieved articles. We included observational studies that examined the association between psoriasis and risk of diabetes. Two reviewers independently assessed eligibility and used a standardized form to collect data from published studies. The study quality was assessed by the Newcastle-Ottawa Scale. A total of 22 eligible studies that included 3,307,516 participants fulfilled the inclusion criteria. Compared to individuals without psoriasis, subjects with psoriasis had a 1.42-fold increased risk of diabetes (95% CI, 1.40-1.45). Findings from this meta-analysis suggest that individuals with psoriasis may have a modestly increased risk of diabetes.

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¹⁷⁷Lu-EDTMP can provide fine whole-body images with the best results when applying medium-energy collimation and collecting the 208 keV energy photons and alternatively by collecting both 208 and 113 keV photons for higher count statistics. The most appropriate time point for imaging is around 24 h after injection.

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Purpose: To analyse the relationship between lower gastrointestinal symptoms and clinicopathological features in colorectal polyp patients. Methods: We retrospectively collected the clinicopathological information of outpatients undergoing colonoscopy atLuhe Hospital Affiliated with Capital Medical University. We performed tendency score matching (PSM) between colorectal polyp patients and polyp-free patients by age and sexat a ratio of 1:1 andthen analysed the relationships between colorectal polyps and clinical symptoms by univariate and multivariate analyses. Results: 1) This study included 2483 patients with colorectal polyps and 2483 polyp-free patients. 2) The proportion of abdominal distension and haematochezia was increased in patients with colorectal polyps (25.6% vs. 22.9%, P = 0.024; 21.5% vs. 16.8%, P = 3.4E-5), but the proportion of diarrhoea wasdecreased (35.1% vs. 37.9%, P = 0.036). 3) Patients with haematochezia usually hadlarger polyp sizes [univariate p= 0.014; multivariate 95% CI1.034 (1.001, 1.069), p = 0.043]. 4) Patients with diarrhoea typically had a smaller polyp size [univariate p = 0.078; multivariate 95% CI0.971(0.944, 0.999), p = 0.043]. 5) Constipation and other symptoms had little correlation with the clinicopathological features of colorectal polyps. Conclusions: Haematochezia is positively correlated with the presence and size of colorectal polyps, and diarrhoea is negatively correlated with the presence and size of colorectal polyps.

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