Due to an increasing number of depression diagnoses and limited effective treatments, researchers continue to explore novel therapeutic strategies for this disorder. Recently, interest has revolved around the use of serotonergic psychedelics to reduce the symptoms of depression. In this systematic review, we summarize the currently available knowledge on the safety and efficacy of psychedelic substances for the treatment of depression. A literature search of the PubMed/MEDLINE database identified 14 clinical trials from the last 10 years that examined the use of psilocybin, MDMA, DMT, or LSD for the treatment of depression symptoms. Some psychedelics, especially psilocybin, demonstrated an ability to reduce depressive symptoms as measured by several psychological scales, which was often sustained for months after the last psychedelic session. Moreover, one study revealed that psilocybin has comparable efficacy to escitalopram in the treatment of depression. None of the studies reported any serious adverse events associated with psychedelic administration. The reviewed studies suggest that psychedelics have great potential in depression therapy and, after addressing and overcoming the current study limitations, may be used as a novel method of treating depression in the future.

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Introduction: The count of psychiatric patients is growing. The same trend it is observed among cardiovascular diseases and metabolic like diabetes. Many people take drugs which may affect on mental state. On the one hand that drugs could have pleotropic mechanism of action which are beginning to use in treatment of psychiatry. The other hand is showed undiscovered field of impact on brain working. Methods and Aim: Shown the psychiatric aspect, like side effects and unusual use, of the most used cardiological drugs. To do this, research of articles was done with the help of data bases such as PubMed and Google Scholar. Results: The most used cardiological drugs are beta blockers, calcium canal blockers, ACE inhibitors, ARBs, nitrates, cilostazol, amiodarone and clonidine In this article it was shown current known about those drugs like mechanism of action and a report of psychiatric clinical trials. Beta-blockers are the most commonly used group of cardiological drugs as the one that significantly affects mental health. Their therapeutic importance has been noted in diseases such as: PTSD or stage fright. It was also long believed that they could make depression worse, but the latest research strongly contradicts this. A positive effect in the treatment of depression can also be obtained by usage of inhibitors of the RAA. Calcium channel blockers are another group of cardiac drugs that are important in the regulation of mood in bipolar disorder. To sum up, a large proportion of cardiac drugs can influence the flow of psychiatric diseases, and the use of them may be clinically desirable in patients with bothcardiac and psychiatric problems.

The major aim of this article was to examine causal connection or temporal relation between mental disorders and lichen planus (LP). LP is a chronic, inflammatory skin condition affecting less than 1% of the adult population. It is observed in many different clinical forms, some affecting more psychical state than others. Indeed, connection exist between LP and mental state. LP as an autoimmune disease can also be aggravated by psychosocial stressors. Etiopatogenesis of LP is idiopathic and involves immunologic components. Main pathogenetic mechanism of LP include increased apoptosis of keratinocytes and decreased apoptosis of T-cells. Many authors report relationship LP between mental illness like depression and anxiety disorder or lack of emotional stability. One of the main symptoms of LP is is severe itch (present in 74 from 78 patients), which can be induced by stress.

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Diagnosis of attention deficit hyperactivity disorder (ADHD) in adolescent patients may be problematic, because of the broad spectrum of symptoms. Population research display heritable character. The function of dopaminergic, adrenergic, and serotoninergic systems is disordered in different ways in patients, who suffer from this disease. Purpose: The aim of this article is to show the actual view on the treatment of attention deficit hyperactivity disorder in teenage patients.. Results: In the treatment of ADHD the most important thing is pedagogical therapy as well as cooperation of parents and medical crew. In some particular cases pharmacologic treatment should also be included in therapeutic process, which is described in this review. Methylphenidate is the most frequent drug used in the treatment and that is why we focused on the complex description of the substance. Conclusions: Teachers and the school responsible for teaching these children must adapt didactic methods to the severity of the disorder. It is valuable to conduct the drug in the therapy of teenagers whose parents ready to cooperate, always with psychiatric supervision. In the process of pharmacotherapy, it is crucial to include breaks, for example during vacations. Psychostimulants are highly addictive substances, which is why many researchers are uncertain about the routine prescription of methylphenidate.

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Stroke remains a leading cause of death and disability worldwide. The cause is decrease or total blocking of blood perfusion in brain and fast recognition is essential to conduct proper treatment. Currently commonly used methods are thrombolysis and mechanical thrombectomy, which high efficacy is observed only if they are performed within a few hours of the first symptoms. Hence loads of people, who are diagnosed later, become unable to undergo effective treatment. In the study are presented pathogenesis, epidemiology, classification, diagnosis and current treatment of the disease, but the main aim of the study is to present the results of the reports on new treatments for ischemic stroke. The research method is a review of the available literature published in PubMed, UpToDate and Google scholar databases. In the study were reviewed new methods, which can be alternative for currently used ones. They are small molecules including fluoxetine, aripiprazole, L-DOPA, cholinergic and 67 noradrenergic drugs, growth factors (HCG, EPO), monoclonal antibodies, allogenic stem cells, neurostimulators, robotic therapy and telerehabilitation. They give hope for curing a larger number of patients and improving effects of rehabilitation after ischemic stroke. However most of the methods, which are presented in this study require the use of tests that will allow checking their safety and application.