We evaluated the relevance of interocular asymmetry of optic disc size to the level of intraocular pressure and the extent of optic disc and visual field changes in normal-tension glaucoma (NTG). Fifty-two eyes of 26 patients with NTG were measured for optic disc topography using a computerized image analysis system (IMAGEnet, Topcon), diurnal intraocular pressure (IOP), and Octopus automated visual field. Of the 26 patients, 22 had interocular asymmetry of the optic disc area of at least 0.01 mm2 and of mean IOP of at least 0.3 mmHg. Of these 22 patients, 8 had the higher mean IOP in the eye with the larger optic disc. In these 8 patients, the visual field defect was significantly more advanced in the eye with the larger optic disc (Wilcoxon signed ranks test, P < 0.05). These findings appear to support the hypothesis that an eye with a large optic disc may be more vulnerable to a rise in IOP.
Three generations of one family (ten males and five females) with two young boys (cousins) and grandfather showing signs of retinoschisis were examined clinically and electrophysiologically. The inheritance of the retinoschisis was determined to be X-linked. The aim of this study was to detect the typical ERG findings in juvenile retinoschisis and to find out any possible ERG changes in female carriers.No clinical findings or ERG abnormalities were detected in obligate or possible carriers of the disease. ERG recordings of the three subjects who had X-linked retinoschisis showed reduced b-wave amplitudes in all rod-mediated and mixed responses. Also most cone-mediated b-waves were subnormal. The b-wave implicit times were increased in some mixed and cone-mediated responses. They showed also some abnormalities in the a-waves.
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