Bone marrow (BM) examination is a routine staging procedure in follicular lymphoma (FL). Commonly, both BM histology as well as flow cytometry (FCM) of BM aspirates are performed. In order to compare the diagnostic value of these two techniques, we retrospectively evaluated trephine BM biopsies and listmode data of patients with a confirmed diagnosis of FL, obtained in parallel during a 5-year period. One hundred and thirty nine specimens from 91 patients with FL were eligible for analysis. After joint review, nine cases (6.5%) were reclassified, either in histology (six cases) or FCM (three cases). Seventy nine specimens (57%) showed no infiltration with both methods. Sixty specimens (43%) were scored positive for BM involvement by any of the two techniques. Concordant positive results were obtained in 41 cases (68% of positive BM). False negative results were obtained by FCM in 14 cases (23% of positive BM) and by histology in five cases (8%). Discrepant results between BM histology and FCM are frequent in patients with FL, most likely due to the predominantly paratrabecular infiltration and fibrosis typical for FL. Due to the lower false negative rate, trephine BM biopsy remains crucial for the detection of BM involvement in FL.
Zusammenfassung Angesichts des rasanten Wachstums seiner Bestände und Magazinstandorte sowie zunehmender technischer Möglichkeiten konzentriert sich das Bundesarchiv stärker denn je auf zeitgemäße massentaugliche Lösungen der Bestandserhaltung. Das Anfang 2022 veröffentlichte neue Bestandserhaltungskonzept erläutert die Grundsätze. Im Sinne einer umfassenden Bestandserhaltung auf der Basis internationaler fachwissenschaftlicher Erkenntnisse verbindet das Bundesarchiv in großem Maßstab Lagerungsthemen einschließlich Bauplanungen mit der Mitgestaltung einschlägiger, auch internationaler, Normen, mit Risikomanagement, dem Vorantreiben der weiteren Professionalisierung in der Restaurierung und dem Ausbau der Digitalisierung.
Zusammenfassung Das Bundesarchiv hat in den letzten Jahren erhebliche Mittel in die Kulturgutdigitalisierung investiert. Das Portal „Weimar – Die erste deutsche Demokratie“ und die dort präsentierten digitalen Objekte waren ein erster wichtiger Meilenstein. Bis zum Jahr 2030 ist die Digitalisierung von insgesamt 400 Millionen Aktenseiten vorgesehen. Dieser Beitrag stellt die drei Programmlinien der Digitalisierung beim Bundesarchiv vor und beschreibt die einzelnen Prozessschritte für deren Operationalisierung. Abschließend werden die noch bestehenden Probleme und das Verhältnis von Digitalisierung und Bestandserhaltung diskutiert.
The point of this review was to assess the ethanolic concentrate of Psidium cattleianum biocompatibility by basic and utilitarian cell reasonability support. Cell practicality was broke down after 1, 3, 6, 10 and 24 hours of hatching by Exclusion Method with trypan blue and MTT measure, utilizing human mononuclear cells [PBMC] and human periodontal tendon [PDL] cells in culture. Positive control utilized was RPMI cell culture medium and negative control was ethanol 80%. The got information were subjected to measurable examination at a criticalness level of 5%. By trypan blue examine, ethanolic remove displayed a homogeneous execution of PBMC from the 1 h, with normal reasonability in the vicinity of 30 and half (p>0.05). By MTT examine, the outcomes demonstrated the adequacy of the ethanolic concentrate of Psidium cattleianum in keeping up the utilitarian reasonability of the periodontal tendon cells to 10 h (p>0.05), displaying values more noteworthy than the RPMI control. In both techniques, it can be watched that the concentrate properties can kill the cytotoxic impact of its diluent ethanol 80%, which indicated normal practicality almost zero (p<0.05). The biocompatibility by auxiliary and useful cell feasibility support was viewed as satisfactory to ethanolic concentrate of Psidium cattleianum and further reviews ought to be performed to demonstrate its utilization as another option to water system arrangement generally utilized as a part of regular practice.
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