A very high catalytic activity in the cyanosilylation reaction was observed for MIL-101, a chromium based metal-organic framework; moreover, MIL-101 is also a remarkably stable support for palladium in hydrogenation reactions, with significantly higher activity than e.g. palladium on activated carbon.
A magnetic functionalization of microcrystalline MOF particles was realized using magnetic iron oxide particles. Such magnetic MOFs can be separated using a static magnetic field after use in catalytic processes and heated by an external alternating magnetic field to trigger desorption of encaged drug molecules.
A modular approach for the synthesis of highly ordered porous and chiral auxiliary (Evans auxiliary) decorated metal-organic frameworks is developed. Our synthesis strategy, which uses known porous structures as model materials for incorporation of chirality via linker modification, can provide access to a wide range of porous materials suitable for enantioselective separation and catalysis. Chiral analogues of UMCM-1 have been synthesized and investigated for the enantioseparation of chiral compounds in the liquid phase and first promising results are reported.
The targeted synthesis of a desired stereomer plays a key role in life sciences, especially in the production of drugs. Up to date, this area is dominated by homogeneous chiral catalysts. Metal-Organic Frameworks (MOFs), a new class of porous materials, consisting of metal-oxo-clusters and multifunctional ligands could offer a platform for chiral heterogeneous catalysts combining the efficiency and in particular selectivity observed for homogeneous asymmetric catalysts with the advantages of heterogeneous catalysis. This review summarizes strategies to obtain chiral Metal-Organic Frameworks and gives an overview about reactions that have been successfully conducted using chiral MOFs as asymmetric catalysts. In addition, some examples highlighting the stereoselective adsorption properties of chiral Metal-Organic Frameworks are given.
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