This research aims to identify and analyze the frequency of the researched determinants and outcomes of absenteeism and thus create an extensive pool of knowledge that can be used for further research. A systematic review, based on Tranfield, Denyer, and Smart’s guidelines of 2003, was used. An electronic search of the Scopus database led to the inclusion of 388 peer-reviewed research articles. Finally, 100 top-quality articles were analyzed using content analysis. This article provides several starting points for practitioners and researchers when investigating absenteeism and its potential determinants and outcomes. It also shows that there is an evident imbalance between empirical research dealing with determinants and research dealing with absenteeism outcomes. Employee attitudes stand out among the most repetitive absenteeism causes, while turnover, organizational health, and loss of productivity are some of the most researched absenteeism outcomes. Most research takes place in the manufacturing industries, followed by hospitals and other public service organizations, banks, and insurance companies. This systematic literature review is the first known attempt of this kind of review of the causes and consequences of absence behavior. It covers a wide range of literature published from 1969 until today and includes more than 150 different absenteeism determinants and outcomes.