The present work provides a fast and mild method towards the synthesis of urea derivatives and their application in amino group protection. This new methodology is an inexpensive, simple, and environmentally safe process for the synthesis of urea derivatives. It is well suited for aliphatic amines and aromatic amines. With aliphatic amines, Zn-mediated urea bond formation occurs at ambient temperature, whereas with aromatic amines, it occurs at 60 °C. Environmentally friendly reaction conditions, sustainability, enumerating tolerance of a wide variety of functional groups, cost-effectiveness, high atom economy, fast reaction time, and adaptability for large-scale synthesis are all benefits of this technology.
The present work provides a simple and mild method towards the synthesis of carbonate derivatives of aliphatic and aromatic alcohols. For various aliphatic and substituted aromatic alcohols the current carbonate formation protocol is suitable. With aliphatic alcohols, Zn‐mediated C−O bond formation occurs in 5 h, whereas with aromatic alcohols, it occurs in 11 h. The utility of zinc dust exhibits a 57–86 % yield of carbonates. Significant advantages of this method including environmentally friendly reaction conditions and the ability to tolerate a wide range of functional groups.
Herein we report an ultrasound‐assisted zinc‐catalyzed solvent‐free process for the synthesis of enaminoketoesters from 1,3 dicarbonyl compounds, N, N‐Dimethylformamide dimethyl acetal (DMFDMA) and various amines with good to excellent yields. This methodology is very much applicable for primary aliphatic, aromatic and secondary alicyclic amines bearing different functional groups. The present work offers the following merits such as inexpensive reagents, one‐pot reaction, eco‐friendly and tolerance to different functional groups with short reaction time.
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