Ag reen, microwave-assisted methodology for the selective direct amidation of carboxylic acids with amines, using montmorillonite K10 as ah eterogeneousc atalyst, has been developed.T his is an efficient transition-metal-free, montmorillonite-K10-catalyzed direct amidation of carboxylic acids. The method is compatible with sterically hindered abranched, aliphatic, benzylic, aromatic,u nsaturated and conjugatedc arboxylic acids. Moreover,c hiral integrity of substratesr emained unchanged after the reaction.
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