Here,
a commercially
available easy-to-handle oxovanadium(V) compound
is demonstrated to serve as an efficient catalyst for the synthesis
of ureas from disilylamines and carbon dioxide under ambient pressure.
The catalytic activation of carbon dioxide proceeds without any additives,
demonstrating a broad substrate scope and easy scalability to validate
this catalytic activation of carbon dioxide. This catalytic system
can be applied to the synthesis of unsymmetric ureas and chiral urea
with retention of chirality.
A sustainable approach for the catalytic synthesis of
unsymmetrical
ureas from disilylamines through catalytic activation of carbon dioxide
as a C1 building block under ambient pressure was performed by using
a commercially available easy-to-handle NH4VO3. This catalytic system displayed a wide range of substrate applicability
without the use of any dehydrating reagents or bases. Gram-scale catalytic
reaction was successfully performed to validate the scalability of
this catalytic synthesis of unsymmetrical ureas under ambient carbon
dioxide pressure.
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