Oxovanadium(V)-Catalyzed Synthesis of Unsymmetrical Ureas by Activation of Carbon Dioxide under Ambient Pressure

Abstract

A sustainable approach for the catalytic synthesis of unsymmetrical ureas from disilylamines through catalytic activation of carbon dioxide as a C1 building block under ambient pressure was performed by using a commercially available easy-to-handle NH4VO3. This catalytic system displayed a wide range of substrate applicability without the use of any dehydrating reagents or bases. Gram-scale catalytic reaction was successfully performed to validate the scalability of this catalytic synthesis of unsymmetrical ureas under ambient carbon dioxide pressure.

Metal‐Catalyzed Carbonylation Reactions with CO2: An Update

“…Here, both symmetrical 36 and unsymmetrical 44 (with the employment of a primary silylamine and a secondary amine) ureas were obtained in high yields (Scheme 20). [29] Importantly, electron‐rich, as well as electron‐poor, silylanilines were found suitable precursors. Despite efficiency, unsymmetrical ureas 44 were always obtained together with large amounts of the symmetrical analogues, derived by the double amination of CO 2 with the primary (silyl)amine.…”