sCD163 levels are increased in patients with chronic viral hepatitis, reflecting macrophage activation. Increased sCD163 is associated with the severity of disease and predicts fibrosis. A sCD163-based fibrosis score, CD163-HCV-FS, is superior to APRI and FIB-4 for the diagnosis of significant fibrosis in patients with HCV infection.
Authors contributions: CR provided data collection, statistical analysis, interpreted data and drafted the manuscript, KK, RY, SE, MM and MS provided the acquisition of data, interpreted data and critically reviewed the manuscript, CB, MG and FS provided the acquisition of data, HJM, MLA, HV, AG and JG interpreted data and critically reviewed the manuscript, EB and HG led the development of the study concept and design, interpreted data, drafted and finalized the manuscript.
Tissue Doppler imaging during rest detected substantial systolic and diastolic myocardial dysfunction in cirrhotic patients. This supports the existence of a distinct cirrhotic cardiomyopathy.
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