2019
DOI: 10.1016/j.jhep.2019.06.031
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Crosstalk between adipose tissue insulin resistance and liver macrophages in non-alcoholic fatty liver disease

Abstract: Authors contributions: CR provided data collection, statistical analysis, interpreted data and drafted the manuscript, KK, RY, SE, MM and MS provided the acquisition of data, interpreted data and critically reviewed the manuscript, CB, MG and FS provided the acquisition of data, HJM, MLA, HV, AG and JG interpreted data and critically reviewed the manuscript, EB and HG led the development of the study concept and design, interpreted data, drafted and finalized the manuscript.

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Cited by 148 publications
(124 citation statements)
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“…Macrophage scavenger receptors have been reported to play an important role in the metabolic 5 homeostasis in adipose tissue (14). In this study, we demonstrate an immunoregulatory role for MSR1 in the presence of lipids, highlighting the metabolic-inflammatory axis between the liver and adipose tissue (24,25). This process was shown to be independent of LPS (19), implementing that MSR1 is crucial in the early development of obesity-induced NAFLD.…”
Section: Fig 1 Macrophage Scavenger Receptor 1 (Msr1) Expression Insupporting
confidence: 54%
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“…Macrophage scavenger receptors have been reported to play an important role in the metabolic 5 homeostasis in adipose tissue (14). In this study, we demonstrate an immunoregulatory role for MSR1 in the presence of lipids, highlighting the metabolic-inflammatory axis between the liver and adipose tissue (24,25). This process was shown to be independent of LPS (19), implementing that MSR1 is crucial in the early development of obesity-induced NAFLD.…”
Section: Fig 1 Macrophage Scavenger Receptor 1 (Msr1) Expression Insupporting
confidence: 54%
“…Consistently with enhanced adipose mass, HFD-fed Msr1 -/mice displayed larger adipocytes along with enhanced fatty acid accumulation within the cells and increased leptin serum levels compared 25 to WT mice, indicating an increased adiposity and fat storage in the absence of Msr1 ( Fig. 2c-d, Fig.…”
Section: Fig 1 Macrophage Scavenger Receptor 1 (Msr1) Expression Inmentioning
confidence: 54%
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