Coronaviruses (CoVs), incorporated positive-sense RNA diseases, are depicted by the club-like spikes that adventure from their surface, an abnormally huge RNA genome, and a specific replication technique. CoVs cause a selection of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory sickness in chickens too possibly deadly human respiratory diseases. Here, we provide a quick presentation to CoVs talking about their replication and pathogenicity, and current avoidance and treatment techniques. We likewise mention the episodes of the profoundly pathogenic severe acute respiratory syndrome CoV (SARS-CoV) and thus the recently identify Middle Eastern respiratory syndrome CoV (MERS-CoV).
Objective: The primary objective of this study was to demonstrate that nebivolol-amlodipine combination therapy is superior to atenolol-amlodipine combination therapy with respect to mean fall in systolic blood pressure (SBP) and diastolic blood pressure (DBP). The secondary objective was to compare the response rate and to evaluate the tolerability of study medications between two treatment groups.The two treatment groups Materials and methods:were similar with respect to demographic characteristics. For data analysis, the whole population was divided into 2 subgroups, escalated patients and non-escalated patients. A total of 190 eligible patients (Nebivolol/Amlodipine combination therapy: 94; Atenolol/Amlodipine: 96) satisfying inclusion/exclusion criteria were enrolled on the study. The results of our study confirmed that the Results and conclusion: combination therapy with Nebivolol /amlodipine is superior to atenolol/Amlodipine combination therapy in patients with mild-to-moderate essential hypertension. In conclusion, our study has shown that once daily treatment with Nebivolol /amlodipine offers superior antihypertensive efficacy over atenolol/Amlodipine combination therapy in patients with mild-to-moderate essential hypertension.
Rheumatoid arthritis are severe in early morning hours, so an attempt has been made to overcome the problem by delaying drug release by colon targeting to maintain peak plasma concentrations in early morning hours. Indomethacin, a non-steroidal anti-inflammatory drug effectively used for treatment of inflammation and pain caused by Half enteric (10% CAP, 10% HPMCP, and 10% EUDRAGIT L-100) coated hydrogel plugs were selected for development of pulsincap in respect to its maximum swelling ratio shown in pH 6.8 compared to the full enteric coated hydrogel plugs. In-vitro release studies were
The prime objective behind this investigation was to plan a Letrozole enclosed adhesive transdermal patch; since the transdermal route is an outright attractive option concerning its route, convenience and safety. Letrozole, a non-steroidal type II aromatase inhibitor, is reported for treating breast tumours and in postmenopausal women. In this study, few factors confined to formulation such as drug-in-adhesive, enhancers and amount of drug-loaded were investigated. The procedure used supposedly involves, the incarnation of the LET in phospholipids exploiting to a spray dryer. FTIR, X-RD, and DSC techniques which are used to evaluate entrapment efficiency were employed to LET spray-dried powder (LT-SDP). The molecule size, polydispersity file, and the EE were allegedly found to be 284.0 nm, 0.247 and 59.08%. On adding LT-SDP to a cream base with peppermint and olive oil as regular infiltration, the optimized formulation showed superior skin targeting in both in vitro and in vivo observations post-study.In vivo bioavailability studies showed just about four-fold increment in the plasma whereas the mean residence time and half-life were reasonably higher as compared to the LET cream in plain. The in vivo results observed remarkable patch concurrence with the plasma fixations anticipated from the in vitro infiltration. As an outpatient convenience, avoidance of gastrointestinal incompatibility provides suitability for self-administration for breast cancer prevention and treatment.
The methanolic extract of leaves of C.dicoccum was evaluated for its hepatoprotective activity against paracetamol induced hepatotoxicity since it is reported to cause oxidative stress in the animal thereby altering the enzymatic levels. Fresh leaves were collected, shade dried and extract was prepared by cold maceration followed by drying in a rota-vapour using methanol to obtain MECD as a sticky semi-solid mass. Thirty rats were taken and divided into 5 equal groups where, Group I, II, and III served as Normal Control, Negative control (PCM 3g/kg), and Positive control (Silymarin 200mg/kg) respectively; whereas, Group IV and V served as test groups where the rats were pre-treated orally with MECD 200mg/kg and 400mg/kg respectively for six days before administering PCM. On the 8 th day all groups except Group I was administered with PCM (3g/kg). 48 hours post PCM induction, the animals were anesthetized, blood samples were obtained via retro-orbital sinus plexus and then the rats were sacrificed. The serum was assessed for the evaluation parameters like AST, ALT, ALP, and bilirubin levels. Apart from these; SOD, CAT, and MDA levels were also evaluated and it was concluded that treatment with MECD restored the levels to normal thereby exhibiting hepatoprotective activity. Moreover, histopathological evaluation was carried out to assess the liver for inflammation, infiltration, or necrosis where the MECD treated rats showed promising results.
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