A Review Novel Coronavirus

Abstract

Coronaviruses (CoVs), incorporated positive-sense RNA diseases, are depicted by the club-like spikes that adventure from their surface, an abnormally huge RNA genome, and a specific replication technique. CoVs cause a selection of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory sickness in chickens too possibly deadly human respiratory diseases. Here, we provide a quick presentation to CoVs talking about their replication and pathogenicity, and current avoidance and treatment techniques. We likewise mention the episodes of the profoundly pathogenic severe acute respiratory syndrome CoV (SARS-CoV) and thus the recently identify Middle Eastern respiratory syndrome CoV (MERS-CoV).

Convalescent Plasma Therapy: A Novel Approach to a Novel Coronavirus

“…After the treatment with CP, there was a drastic improvement in radiology like the resolution of good glass opacities and consolidation in all patients except one patient. Two patients with coronavirus in throat swab elicited the viral load after the therapy (1,5). Increased anti-SARS CoV-2 titre was noticed in two expect one (in 2 nd and 3 rd patient, not in 1 st patient).…”

“…At there is not an antiviral agent that specifically act the target receptor. Therefore the importance of convalescent therapy should be discussed [5].…”

Synthesis and Molecular Modeling Studies of Coumarin‐ and 1‐Aza‐Coumarin‐Linked Miconazole Analogues and Their Antifungal Activity

“…These were brominated according to the method of Koelsch to obtain the corresponding 3‐bromoacetyl coumarins ( 3 ) . Treatment of ( 3 ) with imidazole and benzimidazole in THF at 50–60 °C resulted in the formation of N‐alkylated derivatives ( 4 a‐a′ ) and ( 4 b‐b′ ) respectively . Further, reduction of carbonyl function group of ( 4 a‐a′ ) and ( 4 b‐b′ ) was easily achieved with NaBH 4 in MeOH at 0–5 °C and the corresponding racemic mixtures (5 a‐b) & (5 c‐d) were isolated in good yield.…”

A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing

“…On the other hand, inside the virion, E protein exists in the least quantity and helps release the infected cells’ viral particles (Nal et al 2005 ; Ashour et al 2020 ). Simultaneously, the N protein attaches to the viral RNA, which is obligatory during viral assembly for wrapping the viral RNA into the viral components (Parameshwar et al 2020 ). On the beta-CoV surface, the HE is located.…”