Background. Amide proton transfer (APT) imaging is a novel molecular MRI technique to detect endogenous mobile proteins and peptides through chemical exchange saturation transfer. We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas. Methods. Thirty-six consecutive patients with histopathologically proven diffuse glioma (48.1+14.7 y old, 16 males and 20 females) were included in the study. APT MRI was conducted on a 3T clinical scanner and was obtained with 2 s saturation at 25 saturation frequency offsets v ¼ 26 to +6 ppm (step 0.5 ppm). dB 0 maps were acquired separately for a point-by-point dB 0 correction. APT signal intensity (SI) was defined as magnetization transfer asymmetry at 3.5 ppm: magnetization transfer ratio (MTR) asym ¼ (S [23.5 ppm] 2 S [+3.5 ppm])/S 0. Regions of interest were carefully placed by 2 neuroradiologists in solid parts within brain tumors. The APT SI was compared with World Health Organization grade, Ki-67 labeling index (LI), and cell density. Results. The mean APT SI values were 2.1+0.4% in grade II gliomas (n ¼ 8), 3.2+0.9% in grade III gliomas (n ¼ 10), and 4.1+1.0% in grade IV gliomas (n ¼ 18). Significant differences in APT intensity were observed between grades II and III (P , .05) and grades III and IV (P , .05), as well as between grades II and IV (P , .001). There were positive correlations between APT SI and Ki-67 LI (P ¼ .01, R ¼ 0.43) and between APT SI and cell density (P , .05, R ¼ 0.38). The gliomas with microscopic necrosis showed higher APT SI than those without necrosis (P , .001). Conclusions. APT imaging can predict the histopathological grades of adult diffuse gliomas.

BACKGROUND AND PURPOSE:We investigated the relationship between tumor blood-flow measurement based on perfusion imaging by arterial spin-labeling (ASL-PI) and histopathologic findings in brain tumors.

IVIM imaging is useful in differentiating HGGs from LGGs.

ASL perfusion imaging is useful for differentiating PCNSLs from GBMs as well as DWI and FDG-PET.

BACKGROUND AND PURPOSE: MSDE preparation is a technique for black-blood imaging. Our purpose was to evaluate the usefulness of a 3D TSE sequence with MSDE preparation in detecting brain metastases by comparing it with conventional sequences.

BACKGROUND AND PURPOSE: Glioblastoma multiforme is highly aggressive and the most common type of primary malignant brain tumor in adults. Imaging biomarkers may provide prognostic information for patients with this condition. Patients with glioma with isocitrate dehydrogenase 1 (IDH1) mutations have a better clinical outcome than those without such mutations. Our purpose was to investigate whether the IDH1 mutation status in glioblastoma multiforme can be predicted by using MR imaging.

The 3D FSE Dixon APT method with intrinsic B correction offers a quantitative performance that is similar to that of established two-dimensional (2D) methods. Magn Reson Med 77:2272-2279, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

BACKGROUND AND PURPOSE:Cerebral hemodynamics abnormality in Alzheimer disease (AD) is not fully understood. Our aim was to determine whether regional hypoperfusion due to AD is associated with abnormalities in regional arterial blood volume (rABV) and regional arterial transit time (rATT) as measured by quantitative arterial spin-labeling (ASL) with multiple-delay time sampling.