We report designs for a silicon-on-insulator (SOI) one-dimensional (1D) photonic crystal (PhC) nanocavity with modulated mode-gap barriers based on the lowest dielectric band. These cavities have an ultrahigh theoretical quality factor (Q) of 10(7)-10(8) while maintaining a very small modal volume of 0.6-2.0 (lambda/n)(3), which are the highest Q for any nanocavities with SiO(2) under-cladding. We have fabricated these SOI 1D-PhC cavities and confirmed that they exhibited a Q of 3.6 x 10(5), which is also the highest measured Q for SOI-type PhC nanocavities. We have also applied the same design to 1D PhC cavities with air claddings, and found that they exhibit a theoretical quality factor higher than 10(9). The fabricated air-cladding 1D Si PhC cavities have showed a quality factor of 7.2 x 10(5), which is close to the highest Q value for 1D PhC cavities.

Planet formation theories predict the existence of free-floating planets that have been ejected from their parent systems. Although they emit little or no light, they can be detected during gravitational microlensing events. Microlensing events caused by rogue planets are characterized by very short timescales tE (typically below two days) and small angular Einstein radii θE (up to several μas). Here we present the discovery and characterization of two ultra-short microlensing events identified in data from the Optical Gravitational Lensing Experiment (OGLE) survey, which may have been caused by free-floating or wide-orbit planets. OGLE-2012-BLG-1323 is one of the shortest events discovered thus far (tE = 0.155 ± 0.005 d, θE = 2.37 ± 0.10μas) and was caused by an Earth-mass object in the Galactic disk or a Neptune-mass planet in the Galactic bulge. OGLE-2017-BLG-0560 (tE = 0.905 ± 0.005 d, θE = 38.7 ± 1.6μas) was caused by a Jupiter-mass planet in the Galactic disk or a brown dwarf in the bulge. We rule out stellar companions up to a distance of 6.0 and 3.9 au, respectively. We suggest that the lensing objects, whether located on very wide orbits or free-floating, may originate from the same physical mechanism. Although the sample of ultrashort microlensing events is small, these detections are consistent with low-mass wide-orbit or unbound planets being more common than stars in the Milky Way.

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We report the discovery of OGLE-2016-BLG-1190Lb, which is likely to be the first Spitzer microlensing planet in the Galactic bulge/bar, an assignation that can be confirmed by two epochs of high-resolution imaging of the combined source-lens baseline object. The planet's mass, M p =13.4±0.9 M J , places it right at the deuteriumburning limit, i.e., the conventional boundary between "planets" and "brown dwarfs." Its existence raises the question of whether such objects are really "planets" (formed within the disks of their hosts) or "failed stars" (lowmass objects formed by gas fragmentation). This question may ultimately be addressed by comparing disk and bulge/bar planets, which is a goal of the Spitzer microlens program. The host is a G dwarf, M host =0.89±0.07 M e , and the planet has a semimajor axis a∼2.0 au. We use Kepler K2 Campaign 9 microlensing data to break the lens-mass degeneracy that generically impacts parallax solutions from Earth-Spitzer observations alone, which is the first successful application of this approach. The microlensing data, derived primarily from near-continuous, ultradense survey observations from OGLE, MOA, and three KMTNet telescopes, contain more orbital information than for any previous microlensing planet, but not quite enough to accurately specify the full orbit. However, these data do permit the first rigorous test of microlensing orbital-motion measurements, which are typically derived from data taken over <1% of an orbital period.

Exosomes are involved in a wide range of biological processes in human cells. Considerable evidence suggests that engineered exosomes (eExosomes) containing therapeutic agents can attenuate the oncogenic activity of human cancer cells. Despite its biomedical relevance, no information has been available for oral squamous cell carcinoma (OSCC), and therefore the development of specific OSCC-targeting eExosomes (octExosomes) is urgently needed. We demonstrated that exosomes from normal fibroblasts transfected with Epstein–Barr Virus Induced-3 (EBI3) cDNA were electroporated with siRNA of lymphocyte cytoplasmic protein 1 (LCP1), as octExosomes, and a series of experiments were performed to evaluate the loading specificity/effectiveness and their anti-oral cancer cell activities after administration of octExosomes. These experiments revealed that octExosomes were stable, effective for transferring siLCP1 into OSCC cells and LCP1 was downregulated in OSCC cells with octExosomes as compared with their counterparts, leading to a significant tumor-suppressive effect in vitro and in vivo. Here we report the development of a new valuable tool for inhibiting tumor cells. By engineering exosomes, siLCP1 was transferred to specifically suppress oncogenic activity of OSCC cells. Inhibition of other types of human malignant cells merits further study.

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We present the result of microlensing event MOA-2016-BLG-290, which received observations from the twowheel Kepler (K2), Spitzer, as well as ground-based observatories. A joint analysis of data from K2 and the ground leads to two degenerate solutions of the lens mass and distance. This degeneracy is effectively broken once the (partial) Spitzer light curve is included. Altogether, the lens is found to be an extremely low-mass star or brown dwarf ( -+ M 77 23 34 J ) located in the Galactic bulge (  6.8 0.4 kpc). MOA-2016-BLG-290 is the first microlensing event for which we have signals from three well-separated (∼1 au) locations. It demonstrates the power of twosatellite microlensing experiment in reducing the ambiguity of lens properties, as pointed out independently by S. Refsdal and A. Gould several decades ago.