No abstract

No abstract

No abstract

The aim of the present review is to give a concise analysis of the thermodynamic parameters obtained from isothermal titration microcalorimetry (ITC) experiments for the characterization of the self-organization of surfactants into micelles. This review is also focused on works describing some methods allowing to overcome ITC limitation and to extract accurate thermodynamic values from ITC data.

The cavernous hemangioma is a rare benign vascular tumor. About 50 cases of this disease were found in the literature over the last century and only 9 cases of cavernous hemangioma on the pregnant uterus were published it comes into cavernous or capillary form. The symptomatology is not unequivocal and when it occurs during pregnancy or postpartum, it causes life-threatening cataclysmic hemorrhage. Antenatal diagnosis is difficult and requires a multidisciplinary approach with pathologists, radiologists and gynecologists to avoid these complications or unnecessary hysterectomies. The diagnosis is histological. Hysterectomy is possible after failure of conservative treatment means. We report a rare case, a novel mixed cavernous hemangioma of the body associated with a capillary hemangioma of the cervix in a patient of 28 years 5th visors with recurrent genital bleeding in the postpartum period leading to a hysterectomy.

No abstract

iTo be efficient, vaginal microbicide hydrogels should form a barrier against viral infections and prevent virus spreading through mucus. Multiple particle tracking was used to quantify the mobility of 170-nm fluorescently labeled COOH-modified polystyrene particles (COOH-PS) into thermosensitive hydrogels composed of amphiphilic triblock copolymers with block compositions EO n -PO m -EO n (where EO refers to ethylene oxide and PO to propylene oxide) containing mucoadhesive hydroxypropylmethylcellulose (HPMC). COOH-PS were used to mimic the size and the surface charge of HIV-1. Analysis of COOH-PS trajectories showed that particle mobility was decreased by Pluronic hydrogels in comparison with cynomolgus macaque cervicovaginal mucus and hydroxyethylcellulose hydrogel (HEC; 1.5% by weight The idea exposed in this work is to form a physical barrier composed of thermosensitive and mucoadhesive hydrogel against HIV diffusion, thus limiting virus attachment to mucosal surfaces of the vagina. The thermosensitive property of the (ethylene oxide) 98 (propylene oxide) 67 (ethylene oxide) 98 (EO 98 PO 67 EO 98 ) block copolymer designated Pluronic F127 or poloxamer P407 is particularly interesting for the design of vaginal microbicides acting as a physical barrier. At a certain concentration, this system is fluid at room temperature and in the form of a gel at body temperature (37°C) (1). In contrast to semisolid hydrogels, the administration of the formulation in the form of a solution (for instance, via syringes or another suitable device) facilitates its spreading on the mucosa, while the hydrogel layer on the mucosal surface could allow the formation of a physical barrier against virus diffusion. Mucoadhesion of Pluronic hydrogels was further improved by adding hydroxypropylmethylcellulose (HPMC) as a mucoadhesive polymer (1).Previous works reported different techniques for the investigation of this barrier effect by using viruses or virus-like particles.Diffusion chambers and Transwell-Snapwell chambers were used for hydrogel samples. The principle is based on donor-receptor duality. The sample containing the tracking substance, such as polystyrene particles, is placed in a donor chamber, and their passage in a receiver chamber filled with an appropriate liquid medium is observed (2, 3). However, this technique did not allow control of parameters such as thickness and uniformity of the sample layer, influence of preparation and handling on the structure of the sample, and optimal diameter of the pore to prevent blockage with the hydrogel sample (4). Fluorescence-labeled probe observations using fluorescence recovery after photobleaching (FRAP), single or multiple particle tracking (SPT or

No abstract