Formulation of mucoadhesive vaginal hydrogels insensitive to dilution with vaginal fluids

Thermosensitive and Mucoadhesive Pluronic-Hydroxypropylmethylcellulose Hydrogel Containing the Mini-CD4 M48U1 Is a Promising Efficient Barrier against HIV Diffusion through Macaque Cervicovaginal Mucus

“…Notably, F68 was added to modulate gelling temperature (T gel ), while HPMC was added to improve hydrogel mucoadhesion (1).…”

“…The thermosensitive property of the (ethylene oxide) 98 (propylene oxide) 67 (ethylene oxide) 98 (EO 98 PO 67 EO 98 ) block copolymer designated Pluronic F127 or poloxamer P407 is particularly interesting for the design of vaginal microbicides acting as a physical barrier. At a certain concentration, this system is fluid at room temperature and in the form of a gel at body temperature (37°C) (1). In contrast to semisolid hydrogels, the administration of the formulation in the form of a solution (for instance, via syringes or another suitable device) facilitates its spreading on the mucosa, while the hydrogel layer on the mucosal surface could allow the formation of a physical barrier against virus diffusion.…”

“…In contrast to semisolid hydrogels, the administration of the formulation in the form of a solution (for instance, via syringes or another suitable device) facilitates its spreading on the mucosa, while the hydrogel layer on the mucosal surface could allow the formation of a physical barrier against virus diffusion. Mucoadhesion of Pluronic hydrogels was further improved by adding hydroxypropylmethylcellulose (HPMC) as a mucoadhesive polymer (1).…”

Biodegradable polymers for dental tissue engineering and regeneration

“…PEG and PPG are also linked in the triblock form of pluronic ([PEG]n-[PPG]m-[PEG]n) [275] that allow the formation of small micelles (10-100 nm in diameter) by self-assembly in water for the delivery of chemotherapeutics, antibacterials, antidiuretics, anti-inflammatory drugs, and DNA [275][276][277]. Pluronic is also formulated into hydrogels with relatively weak mechanical properties (maximum shear storage modulus of 13.7 kPa at 20 wt% pluronic) used for drug delivery [278] and soft tissue engineering [279]. The mechanical strength of these polyether-based hydrogels is enhanced through cross-linking with excess acryloyl chloride or methacryloyl chloride yielding to the hydrogels PEG diacrylate (PEGDA; shear storage modulus of 68 kPa at 20 wt%) [280] and PEG dimethacrylate (PEGDMA; shear storage modulus of 125 kPa at 20 wt%) [281] that are used in the delivery of chemotherapeutics, hormones, antibacterials, and anti-inflammatory drugs [282] as well as scaffolds in the engineering of cartilage, bone, endothelial, and vascular tissues [283].…”

Development of in situ poloxamer-chitosan hydrogels for vaginal drug delivery of benzydamine hydrochloride: Textural, mucoadhesive and in vitro release properties

“…Moreover, once gelation occurs, these systems may exhibit mucoadhesion, and so improve retention time in the vaginal cavity. The specific gelation temperature of each thermogelling system is a crucial parameter for their performance, being expected to lie within the range of 25-37 °C [10,11]. Poloxamers are synthetic nonionic triblock polymers of polyoxyethylene and polyoxypropylene copolymers which are synthetic polymers with thermoreversible behavior in aqueous solutions and are widely used in pharmaceutical systems [7] Chitosan is a hydrolyzed polysaccharide derivative of chitin, a biopolymer widespread in nature, that is non-toxic, biocompatible and biodegradable [17].…”