This chemotherapy protocol did not result in a longer time to disease recurrence or OST in this population of dogs. Dual-agent protocols have failed to improve survival times and therefore we conclude that a single-agent protocol using carboplatin may be equally effective with less toxicity.
A 3-year-old Rhodesian Ridgeback was examined because of recurrent pancreatitis of 2 months duration. The dog had signs of abdominal pain and jaundice. Blood biochemical findings were consistent with extrahepatic bile duct obstruction, but on abdominal ultrasonography no cause of obstruction was identified. At surgery a pancreatic pseudocyst was found in the body of the pancreas. Cystoduodenostomy, cystic omentalization and biliary diversion resulted in excellent long-term recovery.
Research DigestPoor-quality studies suggest that vitamin B 6 use is beneficial in premenstrual syndrome QUESTION Is the use of vitamin B 6 (pyridoxine hydrochloride) effective for relieving overall premenstrual symptoms and depressive premenstrual syndrome?
DATA SOURCESStudies were identified by searching MEDLINE , EMBASE (1988EMBASE ( -1996, PsychLIT (1974PsychLIT ( -1997, CINAHL (Cumulative Index to Nursing and Allied Health) (1982)(1983)(1984)(1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997), and the Cochrane Controlled Trials Register with the terms premenstrual syndrome, pyridoxine, premenstrual tension, late luteal phase dysphoric disorder, and premenstrual dysphoric disorder. Bibliographies of relevant articles were scanned, and pharmaceutical companies were contacted.
STUDY SELECTIONPublished and unpublished studies in any language were selected if they were randomized, double-blind, placebocontrolled studies for which data could be acquired. Studies involving multivitamin supplements were included if the supplement contained Ն50 mg of vitamin B 6 . Authors were contacted if additional information was required.
DATA EXTRACTIONData were extracted on participants, dose and preparation of vitamin B 6 , outcome measures, results, withdrawals, side effects, and quality scores. Main outcome was subjective lessening of overall premenstrual symptoms, and a secondary outcome was a decrease in depressive premenstrual symptoms. High-quality studies had scores of 3 on the Jadad scale (maximum: 5 points) and of 6 on the authors' quality rating scale (maximum: 8 points).
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