Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) is a rare genetic disease. The LCHADD treatment is mainly based on special diet. In this diet, energy from long-chain triglycerides (LCT) cannot exceed 10%, however energy intake from the consumption of medium-chain triglycerides (MCTs) should increase. The daily intake of energy should be compatible with energy requirements and treatment should involve frequent meals including during the night to avoid periods of fasting. In fact, there are no recommendations for total content of LCT in all of the allowed food in the LCHADD diet. The aim of the study was to present a new method of diet composition in LCHADD with the use of blocks based on energy exchangers with calculated LCT content. In the study, the diet schema was shown for calculating the energy requirements and LCT content in the LCHADD diet. How to create the diet was also shown, based on a food pyramid developed for patients with LCHADD. The blocks will make it possible, in a quick and simple way, to create a balanced diet which provides adequate energy value, essential nutrients and LCT content. This method can be used by doctors and dietitians who specialize in treating rare metabolic diseases. It can also be used by patients and their families for accurate menu planning with limited LCT content.
Introduction: Adherence to dietary recommendations is an important approach for primary prevention of non-communicable diseases. The aim of the study was to compare energy and selected macronutrients intake with diet between men and women from urban and rural areas who participated in the Polish arm of the Prospective Urban Rural Epidemiological (PURE) study, and to identify the proportion of individuals who did not meet dietary recommendations. Material and methods: The study participants consisted of 1272 women and 753 men, aged 35-70 years from urban (n = 1200) and rural (n = 825) areas of Lower Silesian Voivodeship. Participants' habitual food intake was recorded using country-specific food frequency questionnaire (FFQ). Results: Estimated daily energy intake was higher for men than women (2121 vs. 2074 kcal, p < 0.05). Percentage energy provided by carbohydrates was 48%, by fats was 32%, and by protein was 15%. The average energy intake from saturated fatty acids (SFA) was 12.4%, from monounsaturated 10.9%, while from polyunsaturated fatty acids (PUFA) 5.0%, and the P/S ratio was 0.44. In the diets of 75% participants, the percentage energy provided by SFA was above 10%. About 1/3 of participants did not meet the recommended amount of fiber. The urban participants consumed less energy, fat and protein, but more carbohydrates than their rural counterpart. Conclusions: The diets that were closer to recommendations were observed among women and people residing urban areas compared to men and people residing rural areas. The studied diets were characterised by excessive percentage of energy from SFA and too low from PUFA.
Multiple sclerosis is a demyelinating disease of the central nervous system, occurs most commonly in adults between 20 and 40 years of age. Etiology of this disease is still not known, and one of the analyzed environmental factors is food. In this study, based on literature, discusses the impact of dietary intake of food on the occurrence and development of the disease. This study demonstrated that patients with multiple sclerosis less than healthy people ate bread and cereal products, fish, some vegetables and fruits. While patients often consumed an animal products, whole milk and sweets. It also discusses Swank's diet, which suggest that the severity of symptoms disease may be responsible food of animal origin, which is rich in saturated fatty acids. The author found that patients who comply a diet, after 34 years of application, the risk of death due to multiple sclerosis was three times lower than in those who have not complied with all the dietary recommendations. Moreover, research demonstrated a correlation between deficiency of omega-3, vitamin D, B12, antioxidant vitamins and folic acid in diet, and the development and exacerbation of symptoms of multiple sclerosis. Results of research concerning the relationship between dietary factors and the occurrence and development of this disease are inconclusive why the need is greater the amount thereof in this field. Patients may consider using a diet or supplements, if pharmacotherapy and other alternative and complementary methods do not bring expected effects.
Presenting diet quality of patients with metabolic syndrome (MetS), using a holistic approach is more useful than investigating dietary individual components, but there is still a small amount of research in this area. The aim of this study assessed the diet quality, as measured by the HEI-2015, of MetS patients compared to healthy individuals. The study and control group consisted of 215 patients with MetS and 320 people without MetS, respectively. A nutritional analysis using a semi-quantitative food frequency questionnaire was used to evaluate the nutritional habits in the study and control group. Total HEI-2015 scores were significantly lower in MetS subjects than in those in the control group (65.04 ± 9.71 vs. 66.75 ± 8.88) and the quality of women’s diets was better than the quality of men’s diet (66.83 ± 8.99 vs. 64.75 ± 9.57). We also observed that low HDL-c concentration increased the risk of MetS in the general population the most. Across the population, there was a weak positive correlation between HDL-c concentrations and total HEI-2015 scores and a weak negative correlation between mean waist circumference values and total HEI-2015 scores. HDL-c concentrations may be a key factor in the prevention of MetS and appropriate therapeutic management to increase HDL-c levels may be of key importance in patients diagnosed with MetS.
The disease caused by coronavirus SARS-CoV-2 (COVID-19) can affect almost all organs of the human body, including kidneys. We conducted a one-center study to comprehensively analyze the effects of kidney involvement on the course and outcomes in patients hospitalized with COVID-19, depending on the estimated glomerular filtration rate (eGFR) at admission. Out of the 1958 patients, 1342 (68.54%) had eGFR ≥ 60 mL/min/1.73 m2 (group A) and 616 (31.46%) had eGFR < 60 mL/min/1.73 m2 (group B). Group B was additionally divided into subgroups B1, B2, and B3 based on eGFR. We found that mortality rates during hospitalization, as well as after 90 and 180 days, were much higher in group B than group A. The highest mortality was observed in the B2 subgroup with eGFR of 15–29. The mortality of B patients was associated with comorbidities, respiratory dysfunction, immunological impairment, and more frequent development of AKI. AKI had a negative impact on patients’ survival, regardless of the initial renal function. At discharge, 7.4% of patients had serum creatinine levels 30% higher, or more, as compared to admission. The disease course and outcomes in COVID-19 patients are associated with baseline eGFR; however, AKI during hospitalization is a more significant predictor of poor prognosis regardless of the initial renal function.
Background: Diabetes mellitus is among the most frequent comorbidities worsening COVID-19 outcome. Nevertheless, there are no data regarding the optimal risk stratification of patients with diabetes and COVID-19. Since individual C2HEST components reflect the comorbidities, we assumed that the score could predict COVID-19 outcomes. Material and Methods: A total of 2184 medical records of patients hospitalized for COVID-19 at the medical university center were analyzed, including 473 diabetic patients and 1666 patients without any glucose or metabolic abnormalities. The variables of patients’ baseline characteristics were retrieved to calculate the C2HEST score and subsequently the diabetic and non-diabetic subjects were assigned to the following categories: low-, medium- or high-risk. The measured outcomes included: in-hospital mortality; 3-month and 6-month all-cause mortality; non-fatal end of hospitalization (discharged home/sudden-deterioration/rehabilitation) and adverse in-hospital clinical events. Results: A total of 194 deaths (41%) were reported in the diabetic cohort, including 115 in-hospital deaths (24.3%). The 3-month and 6-month in-hospital mortality was highest in the high-risk C2HEST stratum. The C2HEST score revealed to be more sensitive in non-diabetic-group. The estimated six-month survival probability for high-risk subjects reached 0.4 in both cohorts whereas for the low-risk group, the six-month survival probability was 0.7 in the diabetic vs. 0.85 in the non-diabetic group—levels which were maintained during whole observation period. In both cohorts, receiver operating characteristics revealed that C2HEST predicts the following: cardiogenic shock; acute heart failure; myocardial injury; and in-hospital acute kidney injury. Conclusions: We demonstrated the usefulness and performance of the C2HEST score in predicting the adverse COVID-19 outcomes in hospitalized diabetic subjects.
The aim of the study was to evaluate the mineral content in the diets of amateurs preparing for a marathon. The examined group consisted of 92 women (W), whose average age was 30.8 ±6.7 years and 66 men (M), whose average age was 33.2 ±6.6 years. The evaluation of the mineral content of the diets of the surveyed people was done using three-day dietary records which included one day of the weekend. The average daily sodium content in the diets of women was 1,952.2 ±729.2 mg, and in the diets of men it was 3,093.1 ±1,063.3 mg whereas potassium content was 3,361.6 ±798.5 mg and 3,900.3 ±982.3 mg respectively. The potassium content of less than 90% of fulfilling the norm was observed in the diets of 84.8% of women and 66.7% of men. The average content of calcium in the diets of women and men amounted to 887.5 ±278.8 mg and 1,162.6 ± 434.3 mg/day respectively. The diets of 30.4% of women and 16.7% of men had insufficient calcium content as compared to the norms. The average daily phosphorus and magnesium content was significantly higher in men than in women (1,374.6 ±348.6 vs 1,823.5 ±473.0 mg and 373.4 ±107.1 vs 423.6 ±108.8 mg). Magnesium intake was insufficient in the diets of 14.1% of women and 28.8% of men. The average daily content of iron, zinc and copper in the group of women was: 12.1 mg, 10.1 mg and 1.4 mg, while in the diets of men respectively 14.8 mg, 13.5 mg and 1.5 mg. The highest percentage of diets not fulfilling the norm was found for calcium and potassium in women, and potassium and magnesium for men.
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