Etoricoxib is a potent, orally active, and highly selective COX-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. The present research was undertaken to develop mouth dissolving films of etoricoxib to have rapid onset of action. Mouth dissolving film (MDF) is a better alternate to oral disintegrating tablets due to its novelty, ease of use, and the consequent patient compliance. Solubility enhancement and taste masking of etoricoxib were the two challenges solved by formulating druginclusion complex with beta-cyclodextrin (BCD). MDF prepared by solvent casting etoricoxib-BCD complex along with HPMC as film forming polymer was found to possess desirable physicomechanical properties. In vitro release of etoricoxib from MDF in simulated salivary fluid and 0.1 N HCl was more than 95% within 2 minutes. Taste masking and in vivo disintegration were in acceptable range as assessed by human volunteers. Etoricoxib MDF was further characterized by differential scanning calorimetry, powder X-ray diffraction, and scanning electron microscopy. The index of analgesia shown by etoricoxib MDF was comparable to that of immediate release tablets (100% activity within 40 minutes) in animal studies. Conclusively, the present study documents the development of a commercially viable formula for an MDF of etoricoxib with rapidity in pain management.

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Citrus reticulata var. depressa, commonly known as Hirami lemon, is a native citrus species found in the Taiwan and Okinawa islands of Japan. While several Citrus species are known to...

Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach mainly used to treat erosive esophagitis and other condition involving excess stomach acid such as Zollinger-Ellison syndrome. The objective of present study was to Formulate and Evaluate fast dissolving tablets of Pantoprazole sodium. In the preformulation study, IR Spectra of pure drug and with different polymers showed no interaction (no shift in peak). To enhance faster disintegration rate, super disintigrants such as croscarmallose sodium, Crospovidone and Sodium starch glycolate were tried. To evaluate their role in fast dispersion, they were used in different concentrations hence in the present study 9 formulations were prepared. The prepared tablets were subjected to various parameters like uniformity of weight, hardness, friability, drug content, water absorption ratio, wetting time, in vitro disintegration time and in vitro dissolution studies. The effect of different super disintigrants over the Drug release profile was investigated. In the study, all powder blends showed good flow ability (angle of repose below 30º), bulk density in the range between 0.33-0.37 g/cm 3 tapped density in the range between 0.34 and 0.39 g/cm 3 , and the compressibility index was found to be between 5.83 and 9.98 %, which ensures the blend that may be suitable for direct compression in to tablets. In vitro disintegration time for all formulation batches i.e. F-1 to F-9 showed wide variation in the range between 8.78.64 to 19.35 seconds and % Drug dissolved at 30 seconds. The prepared tablets exhibited satisfactory physico-chemical characteristics. The prepared formulations containing superdisintegrants, Crospovidone Along with microcrystalline cellulose showed faster dispersion and dissolution profile as compared with other two superdisintegrants containing formulations. Moreover, the study revealed Crospovidone showed satisfactory results than the superdisintegrants like croscarmilose sodium and sodium starch glycolate.

This present work deals with the synthesis of new azo derivative based on reaction between Amino pyridine and Para hydroxy benzoic acid. The synthesized compound was determined by spectrum characterization and screened for Antimicrobial and anthelmintic activity.