Formulation Development of Mouth Dissolving Film of Etoricoxib for Pain Management

Senthilkumar, KL; Vijaya, C

doi:10.1155/2015/702963

Cited by 31 publications

(25 citation statements)

References 23 publications

(23 reference statements)

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“…Then they were incubated at 37°C under continuous stirring (PHMP-100thermoshaker, Grant Instruments). In vitro disintegration time is generally measured when films started to break or swell and the dissolution time is measured when they completely dissolve in the medium (27,28). The experiment was carried out in triplicate for each different film composition.…”

Section: Evaluation Of Disintegration Timementioning

confidence: 99%

Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention

Prima

Conigliaro

2019

AAPS PharmSciTech

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Nowadays, chemoprevention by administering natural supplements is considered an attractive strategy to reverse, suppress, or prevent the evolution of premalignant oral lesions. In particular, Barbaloin exhibits anti-proliferative, anti-inflammatory, and anti-cancer properties, and it results useful in multi-therapy with classic chemotherapeutics. Therefore, in this work, mucoadhesive buccal films, as locoregional drug delivery system able to provide a targeted and efficient therapeutic delivery of Barbaloin, are proposed. Thus, Aloin extractloaded Eudragit® RL100 or Eudragit® RS100-based buccal films were designed in order to obtain an easily self-administrable formulation capable of promoting Barbaloin penetration into buccal mucosa and assuring high patient compliance. Large amounts of extract (44%) were loaded into the polymer matrix and six formulations were prepared varying polymers and plasticizers ratios. For all formulations, physical form (thermogravimetric analysisdifferential scanning calorimetry, TGA-DSC), swelling degree, mucoadhesiveness, drug release, and ability to promote drug penetration in mucosa have been investigated. After a sequential selection process, Eudragit RS 100-based film, with low PVP and high plasticizers amounts, emerged as the most promising. It results appropriately flexible, uniform in terms of weight, thickness and drug content, as well as characterized by suitable surface pH, good mucoadhesiveness, and low swelling degree. It displays a Higuchian drug release behavior up to 89% of Barbaloin released, thus demonstrating that diffusion through the matrix is the main release mechanism. Remarkable penetration enhancer properties of film were demonstrated by evidence of Barbaloin accumulation into buccal mucosa up to 10-fold higher than those obtained following administration of Aloin solution.

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Section: Evaluation Of Disintegration Timementioning

confidence: 99%

Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention

Prima

Conigliaro

2019

AAPS PharmSciTech

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“…It is defined by applied stress over strain ratio in the elastic deformation zone. Young's modulus was calculated using the following equation [49]:…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole

et al. 2019

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Sodium alginate and its oligosaccharides through potential antifungal properties might improve the activity of antifungal drugs enhancing their efficacy and potentially reducing the frequency of application. Mucoadhesive buccal films are oral dosage forms designed for maintaining both local or systemic drug effects and seem to be a very promising alternative to conventional oral formulations. Hence, in this study, mucoadhesive buccal films based on the alginate and its oligosaccharide oligomer composed predominantly of mannuronic acid for the administration of posaconazole-antifungal drug from the azole group were developed. As the polymer gelation method, a relatively new freeze-thaw technique was chosen. All prepared formulations were examined for pharmaceutical tests, swelling, mechanical, and mucoadhesive properties. In addition, the influence of sodium alginate (ALG) and alginate oligosaccharides (OLG) on POS antifungal activity on Candida species was performed. It was observed that film formulation containing 1% ALG and 1% OLG (F2) was characterized by optimal mucoadhesive and swelling properties and prolonged drug release up to 5 h. Additionally, it was shown that OLG affected the growth reduction of all tested Candida spp. The obtained data has opened the way for future research for developing OLG-based dosage forms, which might increase the activity of antifungal drugs.

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“…Orodispersible films (ODFs) are flexible, thin polymeric dosage forms offering, among other advantages, rapid disintegration in the mouth and fast release of the active pharmaceutical ingredient (API). Several ODF formulations have made their appearance on the market during the past decade, and many others have been optimised by academic research groups aiming to achieve specific therapeutic performances 1,2 and meet the needs of diverse patient groups Methodologies such as petri dish, and drop/slide frame were proposed by several research groups 5,13,14 and extensively reviewed by others 12,15 however currently a consensus on a standard disintegration methodology for orodispersible formulations has not yet been reached.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

In Vitro Oral Cavity Model for Screening the Disintegration Behavior of Orodispersible Films: A Bespoke Design

Redfearn

Scarpa

Orlu

et al. 2019

Journal of Pharmaceutical Sciences

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The availability of biorelevant methods for the disintegration study of pharmaceutical orodispersible dosage forms is required. The disintegration of orodispersibles should be assessed using in vitro methods that can combine biorelevant volumes of disintegration medium, and mechanical stresses mimicking in vivo conditions. This study proposes an adaptation of a mechanical oral cavity model for the disintegration study of orodispersible films. A periodic compression is applied to the sample in the presence of a biorelevant volume of artificial salivary fluid. Four orodispersible films samples (P1, C1, P2, and C2), differing in polymer type and molecular weight, and Listerine were tested and filmed during disintegration. An image analysis program was developed for the determination of the volume reduction of the film matrix over time, as a descriptor of film disintegration behaviour. Samples P1, and Listerine  showed a volume reduction at 180s of > 90%, C1, P2, and C2 were 85%, 48%, and 37% respectively. The model was able to detect differences in the disintegration behaviour of the four samples, and results were comparable with the benchmark product. The concept of disintegration behaviour of orodispersible films was introduced for the first time as an informative method for the study of orodispersible dosage form.

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Formulation Development of Mouth Dissolving Film of Etoricoxib for Pain Management

Cited by 31 publications

References 23 publications

Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention

Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention

Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole

In Vitro Oral Cavity Model for Screening the Disintegration Behavior of Orodispersible Films: A Bespoke Design

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