Transcatheter arterial chemo-embolization using Lipiodol ® is one of the treatments for hepatocellular carcinoma. During this procedure, it is important to monitor the Lipiodol ® deposited inside tumors. This study proposes a method for measurement of the temperature dependence of the velocity of sound in biological tissues. An ultrasonic pulse-echo method was used to measure the velocity of sound. The temperature coefficients of the velocity of sound for Lipiodol ® was −2.82 m s −1 °C−1 . Values of 1.07 and 1.59 m s −1 °C−1 were obtained for normal rat liver and cancerous liver tissue, respectively. Thus, this procedure may potentially allow for the evaluation of the infiltration of Lipiodol ® inside tumors.
Background
Safety and survival during and after donor nephrectomy (DN) are one of the main concerns in living kidney donors (LKDs). Therefore, kidney (left/right) to be procured should be determined after considering the difficulty of DN, as well as the preservation of remnant renal function (RRF). In this prospective study, we investigated the roles of computed tomography volumetry (CTV) in split renal function (SRF) and established a predictive model for RRF in LKDs.
Methods
We assessed 103 LKDs who underwent DN at our institute. The Volume Analyzer SYNAPSE VINCENT image analysis system were used as CTV. RRF was defined as the estimated glomerular filtration rate (eGFR) 12 months after DN. The association between various factors measured by CTV and RRF were investigated, and a role of CTV on prediction for RRF was assessed.
Results
The median age and the preoperative eGFR were 58 years and 80.7 mL/min/1.73m2, respectively. Each factor measured by CTV showed an association with RRF. The ratio of remnant renal volume to body surface area (RRV/BSA) could predict RRF. In addition, RRV/BSA could predict RRF more accurately when used together with age and 24-h creatinine clearance (CrCl).
Conclusions
Our findings suggest that RRV/BSA measured by CTV can play an important role in predicting RRF, and a comprehensive assessment including age and CrCl is important to determine the kidney to be procured.
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