A Rat Model of Frozen Shoulder Demonstrating the Effect of Transcatheter Arterial Embolization on Angiography, Histopathology, and Physical Activity

Taguchi, Hidehiko; Tanaka, Toshihiro; Nomura, Hideyuki; Fukuoka, Yasushi; Minamiguchi, Kiyoyuki; Taiji, Ryosuke; Takayama, Katsutoshi; Takeda, Maiko; Hatakeyama, Kinta; Inoue, Takashi; Ohbayashi, Chiho; Kichikawa, Kimihiko

doi:10.1016/j.jvir.2020.10.017

Cited by 23 publications

(9 citation statements)

References 17 publications

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“…The vascularity subclass index also increased after injection. This is concordant with the results of Taguchi et al who showed increasing number of neovessels in frozen shoulders in rats [19]. However, no statistical difference was reported in our study.…”

Section: Discussionsupporting

confidence: 93%

“…Piglets show a vascular anatomy close to that of humans and are large enough to be explored using imaging devices used in human clinical practice, contrary to small animal models. They have been widely used as models for endovascular studies [ 8 , 19 , 20 ]. No neovascularization was seen on power ultrasound, although it was reported on angiography, which may be due to a limited sonographer sensibility.…”

Section: Discussionmentioning

confidence: 99%

“…It thus has become essential to better understand these mechanisms. Small animal models of tendinopathy have been developed and successfully used in few studies [ 19 , 20 ]. Some of them specifically studied the development of neovessels [ 21 , 22 , 23 ] that seem to appear between 3 and 15 days after tendinopathy induction [ 24 ], with a peak at day 7 (D7) in rats.…”

Section: Introductionmentioning

confidence: 99%

“…Boesen et al demonstrated that treatment of tendinopathy targeting neovessels could be extrapolated from human studies to animals with the efficacy of sclerosing neovessels in Achille’s tendinopathy in horses [ 25 ]. Furthermore, Taguchi et al showed embolization of these neovessels was efficient in frozen shoulders in rats [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Collagenase-Induced Patellar Tendinopathy with Neovascularization: First Results towards a Piglet Model of Musculoskeletal Embolization

et al. 2021

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Background: Therapeutic strategies targeting neovessels responsible for musculoskeletal chronic pain have emerged, including neovessels embolization. Our study aimed to develop a large animal model of patellar tendinopathy with neovascularization. Methods: Nine 3-month-old male piglets (18 patellar tendons) received percutaneous injections of increasing doses of collagenase (0 to 50 mg) at day 0 (D0). Tendinopathy was evaluated by ultrasound (D7 and D14). Neovascularization was evaluated visually and on angiographies. Bonar score was used for histological analysis (D14). Correlations were evaluated using Spearman’s rank (Rs) test. Results: Research protocol was well tolerated. All tendons were enlarged with a median increase of 31.58% [25–40.28] at D7 (p = 0.244) at D7 and 57.52% [48.41–91.45] at D14 (p = 0.065). Tendons with collagenase injection had more hypoechoic changes, with one tendon rupture (p = 0.012). Neovascularization was reported above 5 mg collagenase (p < 0.01) at D7 and D14 with dose-related neovessels induction (Rs = 0.8, p < 0.001). The Bonar score increased above 5 mg collagenase, correlated with the dose (Rs = 0.666, p = 0.003). Conclusions: The study shows the feasibility, safety and reproducibility of this new large animal model of patellar tendinopathy with neovascularization after collagenase injection. It will allow studying new treatments on direct embolization of neovessels by endovascular approach.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Collagenase-Induced Patellar Tendinopathy with Neovascularization: First Results towards a Piglet Model of Musculoskeletal Embolization

et al. 2021

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“… 22 TAE is suggested to disrupt the dysregulated inflammatory response by reducing the vascular transport of proinflammatory mediators and stimulation of sensory nerves. 24 Taguchi et al 25 induced adhesive capsulitis and neovascularization in rats. Following embolization, rats in the treatment group had fewer neovessels and mononuclear inflammatory cells, and greater running distance, than the sham group.…”

Section: Discussionmentioning

confidence: 99%

Genicular artery embolization for early-stage knee osteoarthritis: results from a triple-blind single-centre randomized controlled trial

Landers

Hely

et al. 2023

Bone Jt Open

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AimsThis study investigated the effects of transcatheter arterial embolization (TAE) on pain, function, and quality of life in people with early-stage symptomatic knee osteoarthritis (OA) compared to a sham procedure.MethodsA total of 59 participants with symptomatic Kellgren-Lawrence grade 2 knee OA were randomly allocated to TAE or a sham procedure. The intervention group underwent TAE of one or more genicular arteries. The control group received a blinded sham procedure. The primary outcome was knee pain at 12 months according to the Knee injury and Osteoarthritis Outcome Score (KOOS) pain scale. Secondary outcomes included self-reported function and quality of life (KOOS, EuroQol five-dimension five-level questionnaire (EQ-5D-5L)), self-reported Global Change, six-minute walk test, 30-second chair stand test, and adverse events. Subgroup analyses compared participants who received complete embolization of all genicular arteries (as distinct from embolization of some arteries) (n = 17) with the control group (n = 29) for KOOS and Global Change scores at 12 months. Continuous variables were analyzed with quantile regression, adjusting for baseline scores. Dichotomized variables were analyzed with chi-squared tests.ResultsOverall, 58 participants provided questionnaire data at 12 months. No significant differences were found for the primary and secondary outcomes, with both groups improving following the procedure. At 12 months, KOOS pain scores improved by 41.3% and 29.4% in the intervention and control groups, respectively. No adverse events occurred. Subgroup analysis indicated that the complete embolization group had significantly better KOOS Sports and Recreation, KOOS Quality of Life, and Global Change scores than the control group; 76.5% of participants who received complete embolization reporting being moderately or much better compared to 37.9% of the control group.ConclusionTAE might produce benefits above placebo, but only when complete embolization of all genicular arteries is performed. Further comparative studies are required before definitive conclusions regarding the effectiveness of TAE can be made.Level of evidence: ICite this article: Bone Jt Open 2023;4(3):158–167.

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Transcatheter Arterial Embolization Using Imipenem/Cilastatin Sodium for Chronic Low Back Pain Resistant to Conservative Treatment: A Pilot Study with 2-Year Follow-Up

Fujiwara

Inui

Shibuya

et al. 2021

Cardiovasc Intervent Radiol

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A Rat Model of Frozen Shoulder Demonstrating the Effect of Transcatheter Arterial Embolization on Angiography, Histopathology, and Physical Activity

Cited by 23 publications

References 17 publications

Collagenase-Induced Patellar Tendinopathy with Neovascularization: First Results towards a Piglet Model of Musculoskeletal Embolization

Collagenase-Induced Patellar Tendinopathy with Neovascularization: First Results towards a Piglet Model of Musculoskeletal Embolization

Genicular artery embolization for early-stage knee osteoarthritis: results from a triple-blind single-centre randomized controlled trial

Transcatheter Arterial Embolization Using Imipenem/Cilastatin Sodium for Chronic Low Back Pain Resistant to Conservative Treatment: A Pilot Study with 2-Year Follow-Up

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