“…However, there is a paucity of comparative clinical trials that are critical in evaluating pain, a subjective parameter. 75 The only prospective randomized clinical trials were recently published by Bagla et al and Landers et al 67,69,76 The first was a multicenter single-blinded RCT comparing GAE with a sham procedure in 21 patients using a 2:1 randomization and allowing crossover to GAE at 1 month. Based on the predefined minimum clinically relevant improvement (16% improvement in WOMAC or 12% improvement in VAS), the response rates were 79%, 0%, and 43% for GAE, sham, and crossover groups, respectively.…”