In Japan, gastric ulcers are often accompanied by marked gastric mucosal atrophy. We evaluated the dual therapy of double-dose lansoprazole and amoxycillin for Helicobacter pylori eradication in Japanese ulcer patients and investigated the effects of intragastric distribution of H. pylori colonization and gastric mucosal atrophy on eradication with this combination therapy. Seventy-six H. pylori-positive ulcer patients received lansoprazole (30 mg) plus amoxycillin (500 mg) twice daily for 2 weeks (LA-60 group), lansoprazole (30 mg once daily) plus amoxycillin (500 mg twice daily) for 2 weeks (LA-30 group) or lansoprazole (30 mg once daily) for 6 or 8 weeks (LPZ group). Infection was evaluated by light microscopy, culture and biopsy urease tests. Helicobacter pylori colonization was classified as localized to the corpus (localized type) or involving the antrum and corpus (whole type). Fundic mucosal atrophy was graded according to endoscopic and histological features. Eradication was achieved in 67.6% in the LA-60 group, 31.6% in the LA-30 group, and 0% in the LPZ group, and moderate or severe histological gastritis was improved in the LA-60 group. Eradication was better in localized-type colonization (92%) than whole-type (56%), and better with fundic mucosal atrophy (84%) than without, but poor in both whole-type colonization and scanty mucosal atrophy (47%). The LA-60 therapy achieves better eradication in Japanese ulcer patients with localized H. pylori colonization and/or gastric mucosal atrophy, which are likely to be important predictors for the successful eradication with dual therapy.
Self-ballasted compact fluorescent lamps (CFLs) have been developed and improved in these twenty years. In Japan, the CFLS that have diffusive glass globes to replace incandescent lamps have been developed, but their sizes were too large to fit in the luminares of incandescent bulbs. Thus, we have developed the self-ballasted CFL of an "A60" bulb shape, which has the maximum diameter of c60 mm and the length of 123 mm. This lamp could be substituted for a 60 W incandescent lamp. In order to realize this lamp size, we opt.imized the discharge tube diameter, filling gas type and pressvre, the shape and makmg process of the dlscharge tube After all the tnple "U" connected tube Is selected, which has a decisive advantage against a multi-folded tube on the luminous maintenance during life, but also has a disadvantage on the luminous run-up characteristics. We investigated the behaviors of mercury, especially the mercury diffusion phenomenon released from the auxiliary amalgam-Wags after ignition by both experiments and calculation. The luminous run-up characteristic has been much improved.
A great number of various electronic compact fluorescent lamps (OFLs) have been developed in the whole world. Although most of them are globeless type, general consumers in Japan have not yet completely got used to the naked light tubes, and they also have a tendency to prefer brighter lamps. Thus, we have developed the 23W electronic CFL with a diffusive glass globe, which generates 1 370 Im on 100V main supply and can be substituted for a 100W ball shaped incandescent lamp. In this paper, we explain the structure and the characteristics of this iamp, and also discuss some important technical issues which are the way to control the mercury vapor pressure by using amalgam and to keep safety at the end of life.
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