The reactions of N‐([1]benzofuro[3,2‐d]pyrimidin‐4‐yl)formamidines with hydroxylamine hydrochloride gave rearranged cyclization products via ring cleavage of the pyrimidine component accompanied by a ring closure of the 1,2,4‐oxadiazole to give N‐[2‐([1,2,4]oxadiazol‐5‐yl)[1]benzofuran‐3‐yl)formamide oximes. N‐([1]Benzothieno[3,2‐d]pyrimidin‐4‐yl)formamidines and N‐(pyrido[2,3‐d]pyrimidin‐4‐yl)formamidines with hydroxylamine hydrochloride gave similar results.
The title reaction leads to rearranged cyclization products via ring cleavage of the pyrimidine component accompanied by a ring closure to give of the 1,2,4-oxadiazole. -(OKUDA*, K.; TSUCHIE, K.; HIROTA, T.; J. Heterocycl. Chem. 49 (2012) 4, 755-762, http://dx.
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