Cytotoxic aggregation of misfolded β‐amyloid (Aβ) proteins is the main culprit suspected to be behind the development of Alzheimer's disease (AD). In this study, Aβ interactions with the novel two‐dimensional (2D) covalent organic frameworks (COFs) as therapeutic options for avoiding β‐amyloid aggregation have been investigated. The results from multi‐scale atomistic simulations suggest that amine‐functionalized COFs with a large surface area (more than 1000 m2/gr) have the potential to prevent Aβ aggregation. Gibb's free energy analysis confirmed that COFs could prevent protofibril self‐assembly in addition to inhibiting β‐amyloid aggregation. Additionally, it was observed that the amine functional group and high contact area could improve the inhibitory effect of COFs on Aβ aggregation and enhance the diffusivity of COFs through the blood‐brain barrier (BBB). In addition, microsecond coarse‐grained (CG) simulations with three hundred amyloids reveal that the presence of COFs creates instability in the structure of amyloids and consequently prevents the fibrillation. These results suggest promising applications of engineered COFs in the treatment of AD and provide a new perspective on future experimental research.

Rapid metal coordination-based formation of a hydrogel is combined with the loading of photoactive nanoparticles and a regenerative drug to establish a multifunctional formulation for cancer therapy and mild-temperature wound healing acceleration.

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