Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair

Abstract

Rapid metal coordination-based formation of a hydrogel is combined with the loading of photoactive nanoparticles and a regenerative drug to establish a multifunctional formulation for cancer therapy and mild-temperature wound healing acceleration.

Engineering a platelet-rich plasma-based multifunctional injectable hydrogel with photothermal, antibacterial, and antioxidant properties for skin regeneration

“…The temperature was recorded every minute using the infrared thermal camera. The photothermal conversion efficiency ( η ) of the AGC–PRP–PDA hydrogel was calculated using the following equation: 7,37,38 Hence, first, the time constant of heat transfer ( τ s ) was calculated by linear time data versus −ln( θ ) from the cooling phase, as follows:…”

“…After incubation for 2 h, the bacterial solution was further re-suspended and diluted 30 times. Then, 100 μL of the diluted bacterial solution was spread on nutrient agar (Merck, Germany) and incubated for 18–24 h. Bacterial colonies were counted in each sample and the bacterial survival ratio was calculated as follows: 38,39 Bacterial survival ratio% = ( N in the sample/ N in the control) × 100,where N is the colony number on a plate.…”

“…The temperature was recorded every minute using the infrared thermal camera. The photothermal conversion efficiency (η) of the AGC-PRP-PDA hydrogel was calculated using the following equation: 7,37,38 η…”

Antioxidant, hemostatic, and injectable hydrogels with photothermal antibacterial activity to accelerate full-thickness wound regeneration

“…The photothermal conversion efficiency (Z) of the Alg-HA-Zn-PDA hydrogel was studied according to the previous method. 45,49,50 To this aim, 1 mL of the Alg-HA-Zn-PDA hydrogel was exposed under 808 nm (1 W cm À2 ) for 10 min. Then, the temperature was recorded every 30 s in the cooling phase for 10 min.…”

All-in-One Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy In Vivo

“…Photothermal therapy (PTT), as a non-chemotherapy interventional strategy that can target a variety of malignant tumors, has been widely used in clinical treatment . − NIR laser irradiation triggers the light-absorbing material to remove tumor tissue by thermal ablation, which gives the characteristics of low toxicity and high specificity. , Although the traditional high-temperature PTT strategy (higher than 50 °C) has made good progress in clinical treatments, it still is difficult to prevent the inevitable threat of thermal diffusion to health, and the possibility of inducing inflammatory diseases limits its further clinical treatments. − Low-temperature PTT (lower than 50 °C) has been developed as an alternative strategy to avoid potential damage to normal cells. − Due to the existence of heat shock proteins (HSPs), during the laser irradiation, HSPs can help tumor cells initiate the thermal protection mechanism. − Additionally, different cell cycle phases exhibited varying sensitivities to temperature, with cells in the S-phase being particularly susceptible . This heightened sensitivity can be attributed to the S-phase’s requirement for extensive DNA synthesis.…”