Objective: To determine the Paracetamol induced liver enzyme (AST/ALT) changes in dengue fever in a tertiary care hospital of Hyderabad. Study Design: Observational Study. Setting: Emergency Department of Medicine, Isra University Hospital, Hyderabad. Period: May 2018 to May 2019. Material & Methods: A total of 100 patients of age ≥12 years with dengue fever were included. AST and ALT levels were obtained in the first week and third week of course of illness. Paracetamol was used for anti-pyretic/analgesia purpose was compared of first week with third week. Statistical analysis was done using SPSS. Chi-square test and student’s t-test were applied as appropriate. P value ≤0.05 was considered as significant. Results: Out of total 100 patients, there were 56% males and 44% females and overall mean age was 35.21±15.13 years. The overall mean weight, height, BMI, and mean duration of fever in days was 61.13±17.26 kg, 1.60±0.14 meter, 23.85±6.73 kg/m2, and 4.20±1.43 days, respectively. Independent t test shows significant mean difference of AST/ALT ratio at 1st week (p=0.000) as well as at 3rd week (p=0.020) according to paracetamol dose. Conclusion: In our study, results showed significant improvement in AST, ALT, and AST/ALT ratio at 1st week and 3rd week.
Objective: The purpose behind this study was to determine the predictors of morbidity and mortality during hospitalization caused by cerebrovascular accident. Study Design: Cross Sectional study. Setting: Emergency Department of Medicine, Isra University Hospital, Hyderabad. Period: October 2017 to May 2018. Material & Methods: We have evaluated a total of 124 patients who presented and were admitted with signs and symptoms of stroke and confirmatory diagnosis was made based on CT scan. All baseline and clinical variables recorded in a structured questionnaire and the data were evaluated in Statistical Package for the Social Sciences (SPSS) version 21.0. Outcome of these patients were observed based on the number of patients died during hospitalization and poor outcome associated predictors. Results: A total of 124 patients were selected for this study. The mean age of patients was 58.52 years (13.44 ± SD). In this observational study we have observed hypertension (N = 106, 85.5%) was the most common predictor of hospitalization among patients with stroke. The overall mortality associated with stroke was 16.13% (20 cases out of total 124). Infection of urinary tract during hospitalization, patients presented with unconsciousness, area of thalamic infarction, involvement of middle cerebral artery, and posterior cerebral artery infarction were the most common predictors of stroke related in-hospital mortality. Conclusion: Overall, corrected stroke related in-hospital mortality rate was 16.13% and patients who presented with loss of consciousness, infection of urinary tract, thalamic infarction, and area involving the middle cerebral artery were associated with higher in-hospital stroke related mortality.
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