Paracetamol induced liver enzyme (AST/ALT) changes in dengue fever.

Abstract

Objective: To determine the Paracetamol induced liver enzyme (AST/ALT) changes in dengue fever in a tertiary care hospital of Hyderabad. Study Design: Observational Study. Setting: Emergency Department of Medicine, Isra University Hospital, Hyderabad. Period: May 2018 to May 2019. Material & Methods: A total of 100 patients of age ≥12 years with dengue fever were included. AST and ALT levels were obtained in the first week and third week of course of illness. Paracetamol was used for anti-pyretic/analgesia purpose was compared of first week with third week. Statistical analysis was done using SPSS. Chi-square test and student’s t-test were applied as appropriate. P value ≤0.05 was considered as significant. Results: Out of total 100 patients, there were 56% males and 44% females and overall mean age was 35.21±15.13 years. The overall mean weight, height, BMI, and mean duration of fever in days was 61.13±17.26 kg, 1.60±0.14 meter, 23.85±6.73 kg/m2, and 4.20±1.43 days, respectively. Independent t test shows significant mean difference of AST/ALT ratio at 1st week (p=0.000) as well as at 3rd week (p=0.020) according to paracetamol dose. Conclusion: In our study, results showed significant improvement in AST, ALT, and AST/ALT ratio at 1st week and 3rd week.