Objectives: The methanolic extract of the leaves of Bombax buonopozense was screened for antidiarrheal effects. Materials and methods: The extract was evaluated for castor oil-induced diarrhoea and enteropooling as well as intestinal transit in rats. Results: Bombax buonopozense significantly (p<0.05) and dose-dependently reduced frequency of stooling in castor oil-induced diarrhoea, castor oil-induced enteropooling and intestinal motility in rats. The oral LD 50 values obtained were greater than 5000mg/ kg in mice. Conclusion: These findings suggest that the methanolic extract of the leaves of B. buonopozense may contain some biologically active ingredients that are active for the treatment of diarrhoea in Nigerian herbal traditional medicine.
The results obtained, provide strong evidence of antiulcer activity of the leaf extract of G. senegalensis and support the traditional uses of the plant for the treatment of ulcer.
Aim of study: Stachytarpheta indica is used as herbal remedy for pains in Nigeria. Methods: To validate this claim, the analgesic, anti-inflammatory and antipyretic effects of the stem bark extract were examined in mice and rats by using acetic acid-induced writhing, tail immersion, xylene and egg albumin-induced paw oedema. While yeast and amphetamine induced pyrexia were used to study antipyretic activity in rats. LD50 of the stem bark extract was carried out to determine its safety. Results: The methanol stem bark extract of Stachytarpheta indica showed significant (p<0.05) dose dependent effect in the parameters assayed. The activity of the extract was comparable to acetylsalicylic acid and morphine respectively. The acute toxicity test was greater than 5000 mg/kg. Conclusions: It may be possible that the methanol stem bark extract of Stachytarpheta indica contains biologically active substances with potential value for the treatment of painful and feverish conditions.
Salacia lehmbachii is an indigenous plant used in traditional medicine in Southern Nigeria for the treatment of fever and inflammatory diseases among other uses. The antipyretic effect of ethanolic leaf extract of S. lehmbachii leaf (100, 200 and 400 mg/kg) was evaluated in Wistar albino rats using brewer's yeast, amphetamine and 2, 4 dinitrophenol to induce fever, while the efficacy of the herbal drug was compared with 20 mg/kg paracetamol. Acute toxicity test (LD 50 ) of the herbal extract was conducted via oral route. The ethanolic leaf extract significantly (p<0.05) exhibited antipyretic activity in rats. The presence of diverse constituents including tannins, saponins, steroids, flavonoids and alkaloids could account for the potency of the ethanol leaf extract of this plant. The findings may be of clinical relevance and further substantiates the traditional use of the plant as antipyretic agent.
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