Relative a1•idity of serum antibodies to putative periodontopathogens in periodontal disease. J Periodont Res 1993; 28: 444-450. •£) Munksgaard. 1993 ELISA was used to determine both the avidity and titre of lgG, lgA and IgM antibodies to the gram-negative anaerobe. Porphyromonas gingil"alis, in tvllenty periodontitis patients enrolled in a longitudinal study of attachment loss and eleven non-periodontitis affected subjects. The avidity and titre of lgG antibodies to Actinobacillus Actinomycetemcomitans were also examined. A crosssectional analysis of the longitudinal patients at baseline and non-periodontally affected controls confirmed earlier findings that IgG and lgA antibody titres to P. gingiva/is were higher in periodontitis patients than in individuals who were not periodontally affected. In this cross-sectional analysis, lgG antibody avidities to P. gingiva/is were not found to be significantly higher in periodontitis than in control subjects (p = 0.065). However, indications of the potential prognostic value of antibody avidity was demonstrated by the higher lgM avidities to P. gingimlis in patients who did not experience attachment loss during the three-month monitoring period than in those who did (p=0.0005).
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