Isolation of a series of antibiotics produced by a new variety of Streptomyces viridochromogenes was attempted, and three main components were obtained as amorphouspowders. They were primarily active against Grampositive bacteria, anaerobic bacteria and mycoplasmaand characterized as new members of sulfur-containing peptidic antibiotics. The antibiotic complex was named sulfomycin.
3-Amino-3-deoxy-d-glucose was isolated from a fermentation broth of a Bacillus species designated as Bacillus aminoglucosidicus. This demonstrated for the first time the presence of a monosaccharide aminodeoxypyranose in nature. The aminosugar was isolated in a high yield by using column chromatography with cation exchange resin. The identity of the product with 3-amino-3-deoxy-d-glucose was completely established by comparing the natural product and its derivatives with synthetic 3-amino-3-deoxy-d-glucose and its corresponding derivatives in elemental analyses, infrared spectra and mixed melting point determination.
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