Abslracl-There have been escalating research interests on areas relating to haptic modality in recent years, especially towards mobile devices. However, there seems to be limited studies in determining the relation between haptic user interfaces and its influence on the playability of mobile games. This paper aims to measure playability of mobile games by comparing two different types of haptic interfaces, namely hard and soft keypad, for mobile gaming. The results show that the participants (N=12) scored highest in using a soft keypad (mean = 591.92, SD = 322.57) as compared to playing games using a hard keypad (mean = 471, SD = 359.29). However, this paper highlights that the majority of users prefer using the hard keypad method in virtue of greater player experience with regards to game play.
Objectives
To test the feasibility of a randomised controlled trial (RCT) of aspirin and/or vitamin D3 in active surveillance (AS) low/favourable intermediate risk prostate cancer (PCa) patients with Prolaris® testing.
Patients and Methods
Newly‐diagnosed low/favourable intermediate risk PCa patients (PSA ≤ 15 ng/ml, International Society of Urological Pathology (ISUP) Grade Group ≤2, maximum biopsy core length <10 mm, clinical stage ≤cT2c) were recruited into a multi‐centre randomised, double‐blind, placebo‐controlled study (ISRCTN91422391, NCT03103152). Participants were randomised to oral low dose (100 mg), standard dose (300 mg) aspirin or placebo and/or vitamin D3 (4000 IU) versus placebo in a 3 × 2 factorial RCT design with biopsy tissue Prolaris® testing. The primary endpoint was trial acceptance/entry rates. Secondary endpoints included feasibility of Prolaris® testing, 12‐month disease re‐assessment (imaging/biochemical/histological), and 12‐month treatment adherence/safety. Disease progression was defined as any of the following (i) 50% increase in baseline PSA, (ii) new Prostate Imaging‐Reporting and Data System (PI‐RADS) 4/5 lesion(s) on multi‐parametric MRI where no previous lesion, (iii) 33% volume increase in lesion size, or radiological upstaging to ≥T3, (iv) ISUP Grade Group upgrade or (v) 50% increase in maximum cancer core length.
Results
Of 130 eligible patients, 104 (80%) accepted recruitment from seven sites over 12 months, of which 94 patients represented the per protocol population receiving treatment. Prolaris® testing was performed on 76/94 (81%) diagnostic biopsies. Twelve‐month disease progression rate was 43.3%. Assessable 12‐month treatment adherence in non‐progressing patients to aspirin and vitamin D across all treatment arms was 91%. Two drug‐attributable serious adverse events in 1 patient allocated to aspirin were identified. The study was not designed to determine differences between treatment arms.
Conclusion
Recruitment of AS PCa patients into a multi‐centre multi‐arm placebo‐controlled RCT of minimally‐toxic adjunctive oral drug treatments with molecular biomarker profiling is acceptable and safe. A larger phase III study is needed to determine optimal agents, intervention efficacy, and outcome‐associated biomarkers.
In this paper, we describe an interactive multimedia art project, namely FaceGrid, using mosaic photography art concept for digital storytelling. Inspired by mosaic photography and a montage concept, FaceGrid was produced by using many small image tiles that were woven and stitched together to form the pixel art design pattern. FaceGrid documents the different ways of living and lifestyles of ordinary folks in a multi-cultural and diverse ethnic society in Malaysia. We use audio-visual documentation methods (photography and film-documentary techniques) to record, capture and archive the different facets of lives and user stories by ordinary people. We then transform those slices of life via digital storytelling technique into an interactive multimedia art project.
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