BackgroundUnderstanding racial influences on human papillomavirus (HPV) distribution in women with atypical squamous cells of undetermined significance (ASCUS) cytology via partial genotyping in a statewide population can inform HPV‐based prevention efforts.MethodsWomen aged 21 to 65 years with any cytology result and partial HPV genotyping for ASCUS triage between January 1, 2014, and December 31, 2017, were included. All women attended a Mississippi State Department of Health clinic. Age, race, cytopathologic, and HPV data were extracted from the electronic health record and analyzed. Cytologic specimens were processed with ThinPrep and HPV testing with the Cobas 4800 assay. HPV genotypes were evaluated in hierarchical categories. Chi‐square tests and multinomial logistic regression models evaluated associations between race and type prevalence.ResultsThere were 43,106 women who underwent cervical cancer screening with cytology and ASCUS triage. Of these, 34,363 (80.2%) had normal cytology, 4672 (10.9%) had ASCUS, 2683 (6.3%) had a low‐grade squamous intraepithelial lesion, and 633 (1.5%) had a high‐grade squamous intraepithelial lesion. Blacks represented 69.3% of the sample and had a higher proportion of HPV‐positive ASCUS (6.5%) in comparison with whites (5.6%). Blacks had significantly decreased odds of HPV‐16 (odds ratio [OR], 0.66; 95% confidence interval [CI], 0.6‐0.9; P = .002) and significantly increased odds for 12 other types (OR, 1.37; 95% CI, 1.2‐1.5; P < .0001) in comparison with whites.ConclusionsIn a diverse population, significant differences in HPV genotypes are shown by race. Importantly, blacks with ASCUS are less likely to be positive for HPV‐16 in comparison with whites. Ongoing work is evaluating the individual genotype prevalence and genotype‐specific risk of precancer by race.
An estimate of the posttest probability of disease that is more relevant for an individual patient can be obtained by adjusting the pretest estimate, taking into account patient characteristics and clinical experience. Using the Herren and colleagues' work, diagnostic test efficacy measures are presented to assist practitioners in determining which tests may be accurate in "ruling in" or "ruling out" disease.
The objective of this review is to evaluate studies to determine the effect of a low-protein, vegetarian diet as compared to a low-protein, animal-based diet on estimated glomerular filtration rates (eGFR) in adults with chronic kidney disease (CKD).
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