Porous metal-organic-frameworks (MOFs) are attractive materials for gas storage, separations, and catalytic reactions. A challenge exists, however, on how to introduce larger pores juxtaposed with the inherent micropores in different forms of MOFs, which would enable new functions and applications. Here we report the formation of heterogeneous pores within MOF particles, patterns, and membranes, using a discriminate etching chemistry, called silver-catalyzed decarboxylation. The heterogeneous pores are formed, even in highly stable MOFs, without altering the original structure. A decarboxylated MOF membrane is shown to have pH-responsive switchable selectivity for the flow-assisted separation of similarly sized proteins. We envision that our method will allow the use of heterogeneous pores for massive transfer and separation of complex and large molecules, and that the capability for patterning and positioning heterogeneous MOF films on diverse substrates bodes well for various energy and electronic device applications.

A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface‐modified ceramic carrier by thiol‐ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells.

A SiCN ceramic microreactor with high temperature tolerance and chemical resistance has been fabricated by a 3D printing method.

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Visible-light-promoted direct arylation of 2H-indazoles using phenyldiazonium salt enabled a single-step and fast synthesis (<1 min) of C3 arylated products in high yields (>65%) in an eosin Y immobilized capillary microreactor.

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The past three decades have seen increasing progress in the integration and process diversification of microfluidic systems for use in chemistry, biochemistry, and analysis. Here we summarize recent achievements in microreaction modules and microseparation units. We look into recent developments of microreaction systems fabricated by various 3D printing techniques for chemical synthetic applications. Moreover, we take a look at the recent achievements of newly developed microseparation technologies with enhanced separation efficiency realized by adopting single or hybrid principles as well as novel device concepts. Emerging technologies of 3D printing have potential to realize a vertically stacking the microchannels and miniaturization of bulky microreaction accessories. When the advanced microreaction systems are integrated with newly developed microseparation technologies, automated synthesis of industrial compounds, such as pharmaceuticals which need multiple types of salification chemistry, will be almost completed. Many opportunities are open to developing innovative microreaction systems with these techniques that can also be highly durable under harsh conditions.

In article number 1900739 by Hongsoo Choi, Dong‐Pyo Kim, and co‐workers, biocompatible ceramic microrobots are developed for cell delivery for the first time. The microrobots are fabricated by 3D laser lithography, and magnetic nanoparticles are immobilized on the surface of the microrobots to manipulate the movement of the microrobots by an external magnetic field.