SUMMARYThis paper presents a complete formulation for three-dimensional hydrodynamic analysis of floating flexible structures subjected to surface regular waves, as well as other excitation forces, by employing a direct tight coupling method. The continuum mechanics-based finite element method is employed to model floating structures with arbitrary geometries, which can account for the geometric nonlinearities and initial stress effects that result from the hydrostatic analysis, whereas the boundary element method is used for the fluid via total potential formulation. The simplicity and generality of the present formulation are revealed as compared with the conventional formulation. Numerical examples demonstrate the general capability of the formulation proposed.

The cold‐compaction densification behavior of silicon nitride (Si3N4) ceramic powder was analyzed using two models: the Shima model and the Cam‐Clay model. Triaxial‐compression experimental data were used to evaluate these two models. Shima models that used Si3N4 matrix material with different yield stresses were discussed. It is clear that the Cam‐Clay model can effectively simulate the cold‐compaction densification behavior of Si3N4 ceramic powder. The Shima model that used a very high yield stress for the Si3N4 matrix material slightly overestimated the experimental data, and the Shima model that used the actual yield stress for Si3N4 matrix material largely overestimated that data.

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Type 2 diabetes mellitus (T2DM) is a major public medical problem with ill‐defined pathophysiological mechanisms and multifactorial etiology. Increasing epidemiological studies have consistently suggested an association between persistent organic pollutant (POPs) and risk of developing T2DM. The POPs have also been reported to negatively affect reproductive, central nervous, or the immune system. In this study, the potential mechanism of POPs induced T2DM was investigated by quantitative proteomics. Five general POPs mixtures, p,p’‐DDT, heptachlor, β‐HCH, hexachlorobenzene and chlorodane were administered to zebrafish for 3 months. Proteomic analysis revealed upregulation of protein Pentaxin in zebrafish. Pentaxin is homologous to C‐reactive protein (CRP) in human, which is widely recognized as an independent risk factor for type 2 diabetes. This finding showed that POPs might be a diabetes inducer. Thus, this study increased the understanding of the relationship between POPs and T2DM in biological and proteomics aspects.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.