Comparative proteomics of Zebrafish liver in 5 POPs mixture exposure

Abstract

Type 2 diabetes mellitus (T2DM) is a major public medical problem with ill‐defined pathophysiological mechanisms and multifactorial etiology. Increasing epidemiological studies have consistently suggested an association between persistent organic pollutant (POPs) and risk of developing T2DM. The POPs have also been reported to negatively affect reproductive, central nervous, or the immune system. In this study, the potential mechanism of POPs induced T2DM was investigated by quantitative proteomics. Five general POPs mixtures, p,p’‐DDT, heptachlor, β‐HCH, hexachlorobenzene and chlorodane were administered to zebrafish for 3 months. Proteomic analysis revealed upregulation of protein Pentaxin in zebrafish. Pentaxin is homologous to C‐reactive protein (CRP) in human, which is widely recognized as an independent risk factor for type 2 diabetes. This finding showed that POPs might be a diabetes inducer. Thus, this study increased the understanding of the relationship between POPs and T2DM in biological and proteomics aspects.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.