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Background Data comparing outcomes in heart failure ( HF ) across Asia are limited. We examined regional variation in mortality among patients with HF enrolled in the ASIAN ‐HF (Asian Sudden Cardiac Death in Heart Failure) registry with separate analyses for those with reduced ejection fraction ( EF ; <40%) versus preserved EF (≥50%). Methods and Results The ASIAN ‐ HF registry is a prospective longitudinal study. Participants with symptomatic HF were recruited from 46 secondary care centers in 3 Asian regions: South Asia (India), Southeast Asia (Thailand, Malaysia, Philippines, Indonesia, Singapore), and Northeast Asia (South Korea, Japan, Taiwan, Hong Kong, China). Overall, 6480 patients aged >18 years with symptomatic HF were recruited (mean age: 61.6±13.3 years; 27% women; 81% with HF and reduced r EF ). The primary outcome was 1‐year all‐cause mortality. Striking regional variations in baseline characteristics and outcomes were observed. Regardless of HF type, Southeast Asians had the highest burden of comorbidities, particularly diabetes mellitus and chronic kidney disease, despite being younger than Northeast Asian participants. One‐year, crude, all‐cause mortality for the whole population was 9.6%, higher in patients with HF and reduced EF (10.6%) than in those with HF and preserved EF (5.4%). One‐year, all‐cause mortality was significantly higher in Southeast Asian patients (13.0%), compared with South Asian (7.5%) and Northeast Asian patients (7.4%; P <0.001). Well‐known predictors of death accounted for only 44.2% of the variation in risk of mortality. Conclusions This first multinational prospective study shows that the outcomes in Asian patients with both HF and reduced or preserved EF are poor overall and worst in Southeast Asian patients. Region‐specific risk factors and gaps in guideline‐directed therapy should be addressed to potentially improve outcomes. Clinical Trial Registration URL : https://www.clinicaltrials.gov/ . Unique identifier: NCT 01633398.

We propose a systematic approach to computing the BPS spectrum of any 5d/6d supersymmetric quantum field theory in Coulomb phases, which admits either gauge theory descriptions or geometric descriptions, based on the Nakajima-Yoshioka’s blowup equations. We provide a significant generalization of the blowup equation approach in terms of both properly quantized magnetic fluxes on the blowup $$ \hat{\mathrm{\mathbb{C}}} $$ ℂ ̂ 2 and the effective prepotential for 5d/6d field theories on the Omega background which is uniquely determined by the Chern-Simons couplings on their Coulomb branches. We employ our method to compute BPS spectra of all rank-1 and rank-2 5d Kaluza-Klein (KK) theories descending from 6d $$ \mathcal{N} $$ N = (1, 0) superconformal field theories (SCFTs) compactified on a circle with/without twist. We also discuss various 5d SCFTs and KK theories of higher ranks, which include a few exotic cases such as new rank-1 and rank-2 5d SCFTs engineered with frozen singularity as well as the 5d SU(3)8 gauge theory currently having neither a brane web nor a smooth shrinkable geometric description. The results serve as non-trivial checks for a large class of non-trivial dualities among 5d theories and also as independent evidences for the existence of certain exotic theories.

We generalize Nakajima-Yoshioka blowup equations to arbitrary gauge group with hypermultiplets in arbitrary representations. Using our blowup equations, we compute the instanton partition functions for 4d N = 2 and 5d N = 1 gauge theories for arbitrary gauge theory with a large class of matter representations, without knowing explicit construction of the instanton moduli space. Our examples include exceptional gauge theories with fundamentals, SO(N) gauge theories with spinors, and SU(6) gauge theories with rank-3 antisymmetric hypers. Remarkably, the instanton partition function is completely determined by the perturbative part.